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504519 CIQ - CAS 486427-17-2 - Calbiochem

CIQ - CAS 486427-17-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (3-Chlorophenyl) [3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]methanone

Primary Target: NMDA receptors
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
486427-17-2C₂₆H₂₆ClNO₅

Products

Catalog NumberPackaging Qty/Pack
5.04519.0001 Glass bottle 5 mg
Description
OverviewA positive allosteric modulator selective for NR2C/D containing NMDA receptors (EC50 = 2.7 and 2.8 µM for NR2C and NR2D, respectively). Increases channel opening frequency of recombinant NR2C/D containing NMDA receptors by two-fold without altering mean open time or EC50 values for glutamate or glycine bindings. No effect on NR2A or NR2B subtypes.
Catalogue Number504519
Brand Family Calbiochem®
Synonyms(3-Chlorophenyl) [3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]methanone
References
ReferencesMullasseril, P., et al. 2010. Nat. Commun. 1, 1038.
Ogden, K., et al. 2013. Mol. Pharmacol. 83, 1045.
Product Information
CAS number486427-17-2
FormWhite powder
Hill FormulaC₂₆H₂₆ClNO₅
Chemical formulaC₂₆H₂₆ClNO₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNMDA receptors
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

CIQ - CAS 486427-17-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Mullasseril, P., et al. 2010. Nat. Commun. 1, 1038.
Ogden, K., et al. 2013. Mol. Pharmacol. 83, 1045.

Brochure

Title
Pathways and Biomarkers of Glutamatergic Synapse Flyer
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-June-2013 JSW
Synonyms(3-Chlorophenyl) [3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]methanone
DescriptionA positive allosteric modulator selective for NR2C/D containing NMDA receptors (EC50 = 2.7 and 2.8 µM for NR2C and NR2D, respectively). Increases channel opening frequency of recombinant NR2C/D containing NMDA receptors by two-fold without altering mean open time or EC50 values for glutamate or glycine bindings. No effect on NR2A or NR2B subtypes.
FormWhite powder
CAS number486427-17-2
Chemical formulaC₂₆H₂₆ClNO₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml). Slight warming is required for complete solubilization.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesMullasseril, P., et al. 2010. Nat. Commun. 1, 1038.
Ogden, K., et al. 2013. Mol. Pharmacol. 83, 1045.