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219672 CFTR Inhibitor III, OXO-172 - Calbiochem

219672
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₈H₁₀F₃NO₄S

Pricing & Availability

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219672-10MG
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      Plastic ampoule 10 mg
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      Description
      OverviewA cell-permeable CFTRinh-172 (Cat. No. 219670) 2-oxo analog that exhibits ~25-fold higher aqueous solubility than the 2-thioxo CFTRinh-172 (420 µM vs. 17 µM, respectively, in PBS with 2% DMSO at 25 °C) and great potency, albeit slightly weaker than that of CFTRinh-172, in inhibiting CFTR-mediated apical membrane chloride current upon 20 µM Forskolin (Cat. No. 344270) stimulation in CFTR-expressing FRT cells (IC50 = 1.4 µM vs. 0.38 µM with CFTRinh-172) with practically no cytotoxicity (91% of no-drug control FRT in viability assay; 48 h at 50 µM).
      Catalogue Number219672
      Brand Family Calbiochem®
      Synonyms3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-4-thiazolidinone, OXO-172
      References
      ReferencesSonawane, N.D., and Verkman, A.S. 2008. Bioorg. Med. Chem. 16, 8187.
      Product Information
      FormOff-white solid
      Hill FormulaC₁₈H₁₀F₃NO₄S
      Chemical formulaC₁₈H₁₀F₃NO₄S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC and NMR
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38-43

      Irritating to eyes, respiratory system and skin.
      May cause sensitization by skin contact.
      S PhraseS: 26-36/37-45-61

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing and gloves.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Avoid release to the environment. Refer to special instructions/safety data sheet.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      CFTR Inhibitor III, OXO-172 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      CFTR Inhibitor III, OXO-172 - Calbiochem Certificates of Analysis

      TitleLot Number
      219672

      References

      Reference overview
      Sonawane, N.D., and Verkman, A.S. 2008. Bioorg. Med. Chem. 16, 8187.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-November-2011 RFH
      Synonyms3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-4-thiazolidinone, OXO-172
      DescriptionA cell-permeable CFTRinh-172 (Cat. No. 219670) 2-oxo analog that exhibits ~25-fold higher aqueous solubility than the 2-thioxo CFTRinh-172 (420 µM vs. 17 µM, respectively, in PBS with 2% DMSO at 25 °C) and great potency, albeit slightly weaker than that of CFTRinh-172, in inhibiting CFTR-mediated apical membrane chloride current upon 20 µM Forskolin (Cat. No. 344270) stimulation in CFTR-expressing FRT cells (IC50 = 1.4 µM vs. 0.38 µM with CFTRinh-172) with practically no cytotoxicity (91% of no-drug control FRT in viability assay; 48 h at 50 µM).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₈H₁₀F₃NO₄S
      Structure formulaStructure formula
      Purity≥95% by HPLC and NMR
      SolubilityDMSO (50 mg/ml) or Ethanol (1 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesSonawane, N.D., and Verkman, A.S. 2008. Bioorg. Med. Chem. 16, 8187.