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203600 Bohemine

A synthetic, cell-permeable, cyclin-dependent kinase (CDK) inhibitor that is structurally similar to Olomoucine and Roscovitine.

Bohemine MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: [6-Benzylamino-2-(3-hydroxypropylamino)-9-isopropylpurine

Primary Target: CDK
203600
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
189232-42-6C₁₈H₂₄N₆O

Products

Catalog NumberPackaging Qty/Pack
203600-1MG Plastic ampoule 1 mg
Description
Overview

This product has been discontinued.





A synthetic, cell-permeable, cyclin-dependent kinase (CDK) inhibitor (IC50 = 1 µM) that is structurally similar to Olomoucine (Cat. No. 495620) and Roscovitine (Cat. No. 557360). Arrests cell cycle in the G1/S boundary and activates in vitro matured bovine oocytes either alone or in combination with Ionomycin (Cat. Nos. 407950 and 407952).
Catalogue Number203600
Brand Family Calbiochem®
Synonyms[6-Benzylamino-2-(3-hydroxypropylamino)-9-isopropylpurine
References
ReferencesChmela, Z., et al. 2001. Drug Metab. Dispos. 29, 326.
Alberio, R., et al. 2000. Mol. Reprod. Dev. 55, 422.
Binarova, P., et al. 1998. Plant J. 16, 697.
Product Information
CAS number189232-42-6
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₈H₂₄N₆O
Chemical formulaC₁₈H₂₄N₆O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCDK
Primary Target IC<sub>50</sub>1 µM inhibiting cyclin-dependent kinase (CDK)
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Bohemine Certificates of Analysis

TitleLot Number
203600

References

Reference overview
Chmela, Z., et al. 2001. Drug Metab. Dispos. 29, 326.
Alberio, R., et al. 2000. Mol. Reprod. Dev. 55, 422.
Binarova, P., et al. 1998. Plant J. 16, 697.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-August-2010 JSW
Synonyms[6-Benzylamino-2-(3-hydroxypropylamino)-9-isopropylpurine
DescriptionA synthetic, cell-permeable, cyclin-dependent kinase (Cdk) inhibitor (IC50 = 1 µM) that is structurally similar to Olomoucine (Cat. No. 495620) and Roscovitine (Cat. No. 495620). Arrests cell cycle in the G1/S boundary and activates matured bovine oocytes either alone or in combination with Ionomycin (Cat. No. 407950 and 407952). Reported to transiently arrest Vicia faba root tip cells at the G1/S and G2/M regulatory points and causes abnormal spindle formation.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number189232-42-6
Chemical formulaC₁₈H₂₄N₆O
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml) or Methanol (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
Toxicity Standard Handling
ReferencesChmela, Z., et al. 2001. Drug Metab. Dispos. 29, 326.
Alberio, R., et al. 2000. Mol. Reprod. Dev. 55, 422.
Binarova, P., et al. 1998. Plant J. 16, 697.