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504463 BINA - CAS 866823-73-6 - Calbiochem

BINA - CAS 866823-73-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Biphenyl-indanone A

Primary Target: mGlu₂
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504463
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
866823-73-6C₃₀H₃₀O₄

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      Description
      OverviewA selective positive allosteric modulator for mGlu receptor subtype 2 (EC50 = 33.2 nM in CHO cells expressing human mGlu2). No effect on other mGlu receptor subtypes. Exhibits antipsychotic and anxiolytic properties in mice.
      Catalogue Number504463
      Brand Family Calbiochem®
      SynonymsBiphenyl-indanone A
      References
      ReferencesBonnefous, C., et al. 2005. Bioorg. Med. Chem. Lett. 15, 4354.
      Galici, R., et al. 2006. J. Pharmacol. Exp. Ther. 318, 173.
      Benneyworth, M., et al. 2007. Mol. Pharmacol. 72, 477.
      Sheffler, D., et al. 2011. ACS Chem. Neurosci. 2, 382.
      Product Information
      CAS number866823-73-6
      FormWhite powder
      Hill FormulaC₃₀H₃₀O₄
      Chemical formulaC₃₀H₃₀O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetmGlu₂
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      BINA - CAS 866823-73-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Bonnefous, C., et al. 2005. Bioorg. Med. Chem. Lett. 15, 4354.
      Galici, R., et al. 2006. J. Pharmacol. Exp. Ther. 318, 173.
      Benneyworth, M., et al. 2007. Mol. Pharmacol. 72, 477.
      Sheffler, D., et al. 2011. ACS Chem. Neurosci. 2, 382.

      Brochure

      Title
      Pathways and Biomarkers of Glutamatergic Synapse Flyer
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-June-2013 JSW
      SynonymsBiphenyl-indanone A
      DescriptionA selective positive allosteric modulator for mGlu receptor subtype 2 (EC50 = 33.2 nM in CHO cells expressing human mGlu2). No effect on other mGlu receptor subtypes. Exhibits antipsychotic and anxiolytic properties in mice.
      FormWhite powder
      CAS number866823-73-6
      Chemical formulaC₃₀H₃₀O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (18 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBonnefous, C., et al. 2005. Bioorg. Med. Chem. Lett. 15, 4354.
      Galici, R., et al. 2006. J. Pharmacol. Exp. Ther. 318, 173.
      Benneyworth, M., et al. 2007. Mol. Pharmacol. 72, 477.
      Sheffler, D., et al. 2011. ACS Chem. Neurosci. 2, 382.