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534360 Autophagy Inhibitor VII - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₀H₂₆ClN₃

Products

Catalog NumberPackaging Qty/Pack
5.34360.0001 25 mg
Description
OverviewA cell-permeable tetrahydroacridinamine (THA) derived compound that potently suppresses autophagy (EC = 250 nM) with reduced toxicity (LD50 = 27 µM) in U2OS cells. Shown to induce lysosome deacidification and increase LC3-II protein accumulation. Displays attractive biophysical properties.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number534360
Brand Family Calbiochem®
Synonyms6-Chloro-N-(1-ethylpiperidin-4-yl)-1,2,3,4-tetrahydroacridin-9-amine, Acridinamine 33, Tetrahydroacridine 33, THA33
DescriptionAutophagy Inhibitor VII
References
ReferencesWang, T., et al. 2015. J. Med. Chem. 58, 3025.
Product Information
FormPale yellow solid
FormulationSupplied as HCl salt.
Hill FormulaC₂₀H₂₆ClN₃
Chemical formulaC₂₀H₂₆ClN₃
Hygroscopic Hygroscopic
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
5.34360.00014054839059254

Documentation

Autophagy Inhibitor VII - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Wang, T., et al. 2015. J. Med. Chem. 58, 3025.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-June-2016 JSW
Synonyms6-Chloro-N-(1-ethylpiperidin-4-yl)-1,2,3,4-tetrahydroacridin-9-amine, Acridinamine 33, Tetrahydroacridine 33, THA33
DescriptionA cell-permeable tetrahydroacridinamine (THA) derived compound that potently suppresses autophagy (EC = 250 nM) with reduced toxicity (LD50 = 27 µM) in U2OS cells. Shown to induce lysosome deacidification and increase LC3-II protein accumulation. Displays attractive biophysical properties.
FormPale yellow solid
FormulationSupplied as HCl salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₀H₂₆ClN₃
Purity≥98% by HPLC
SolubilityH₂O (50 mg/ml) or DMSO (1.6 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesWang, T., et al. 2015. J. Med. Chem. 58, 3025.