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532605 Aurora A/MYCN Dual Inhibitor, CD532 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₆H₂₅F₃N₈O

Products

Catalog NumberPackaging Qty/Pack
5.32605.0001 Glass bottle 10 mg
Description
OverviewA cell permeable diaminopyrimidine derived compound that acts as a highly potent and selective inhibitor of Aurora A (IC50 = 48 nM). Acts by binding to the hinge region via a pyrazole moiety and stabilizes a DFG-in, inactive conformation of Aurora A. Potentiates the loss of the wild-type MYCN protein by disrupting MYCN-Aurora A complex and allowing its ubiquitination and proteasomal degradation in MYCN-amplified SK-N-BE (2) and Kelly neuroblastoma cells (EC50 = 223 and 146.7 nM, respectively). Causes a loss of S-phase entry of cells and allows their accumulation in both G0/G1 and G2 phases. Shown to be effective in vivo with serum t1/2 = 1.5 h in mice.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number532605
Brand Family Calbiochem®
SynonymsAurora A Inhibitor, CD532, MYCN Inhibitor, CD532
References
ReferencesLee, J.K., et al. 2016. Cancer Cell. 29, In press.
Gustafson, W. C., et al. 2014. Cancer Cell. 26, 414.
Product Information
FormTan solid
Hill FormulaC₂₆H₂₅F₃N₈O
Chemical formulaC₂₆H₂₅F₃N₈O
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetAurora A
Primary Target IC<sub>50</sub>48 nM
Secondary targetMYCN
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.32605.0001 04055977281804

Documentation

Aurora A/MYCN Dual Inhibitor, CD532 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Lee, J.K., et al. 2016. Cancer Cell. 29, In press.
Gustafson, W. C., et al. 2014. Cancer Cell. 26, 414.

Technical Info

Title
Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
White Paper: Further considerations of antibody validation and usage.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-March-2015 JSW
SynonymsAurora A Inhibitor, CD532, MYCN Inhibitor, CD532
DescriptionA cell permeable diaminopyrimidine derived compound that acts as a highly potent and selective inhibitor of Aurora A (IC50 = 48 nM). Acts by binding to the hinge region via a pyrazole moiety and stabilizes a DFG-in, inactive conformation of Aurora A. Potentiates the loss of the wild-type MYCN protein by disrupting MYCN-Aurora A complex and allowing its ubiquitination and proteasomal degradation in MYCN-amplified SK-N-BE (2) and Kelly neuroblastoma cells (EC50 = 223 and 146.7 nM, respectively). Causes a loss of S-phase entry of cells and allows their accumulation in both G0/G1 and G2 phases. Shown to be effective in vivo with serum t1/2 = 1.5 h in mice.
FormTan solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₆H₂₅F₃N₈O
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLee, J.K., et al. 2016. Cancer Cell. 29, In press.
Gustafson, W. C., et al. 2014. Cancer Cell. 26, 414.