531709 Apoptosis Activator IX, DPP-23 - Calbiochem

Apoptosis Activator IX, DPP-23 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Unfolded Protein Response Inducer, DPP-23, UPR Inducer, DPP_23

531709
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₈H₁₈O₄

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.31709.0001
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          		 Glass bottle 25 mg
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          Description
          OverviewA cell-permeable chalcone derivative that enhances the production of reactive oxygen species and reduces glutathione levels selectively in cancer cells while sparing normal cells and induces unfolded protein response (UPR) through up-regulating UPR related genes. Inhibits the growth of in multiple cancer cell lines (Capan-1, MDA-MB231, HCT116, and HT1080 cells) and suppresses the growth of HCT116 tumor xenografts in nude mice via the induction of apoptosis (10 mg/kg, i.p; q.d.). Arrests cell cycle at the G2/M phase and triggers protective autophagy and induces apoptosis by increasing the active forms of caspase 3, 7, and 9. Treatment of serum-starved MIA PaCa-2 cells with DPP-23 induces the phosphorylation of ERK1/2, JNK1/2, and p38 MAPK in a time-dependent manner.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number531709
          Brand Family Calbiochem®
          SynonymsUnfolded Protein Response Inducer, DPP-23, UPR Inducer, DPP_23
          References
          ReferencesShin, Y.S., et al. 2014. Clin. Cancer Res. 20, in press.
          Product Information
          FormOff-white solid
          Hill FormulaC₁₈H₁₈O₄
          Chemical formulaC₁₈H₁₈O₄
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Apoptosis Activator IX, DPP-23 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Shin, Y.S., et al. 2014. Clin. Cancer Res. 20, in press.

          Brochure

          Title
          NPI Flyer- Epigenetics and Nuclear Function Feature (EMD)
          New Products - Antibodies, Small Molecule, Inhibitors

          Technical Info

          Title
          White Paper: Further considerations of antibody validation and usage. (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-December-2014 JSW
          SynonymsUnfolded Protein Response Inducer, DPP-23, UPR Inducer, DPP_23
          DescriptionA cell-permeable chalcone derivative that enhances the production of reactive oxygen species and reduces glutathione levels selectively in cancer cells while sparing normal cells and induces unfolded protein response (UPR) through up-regulating UPR related genes. Inhibits the growth of in multiple cancer cell lines (Capan-1, MDA-MB231, HCT116, and HT1080 cells) and suppresses the growth of HCT116 tumor xenografts in nude mice via the induction of apoptosis (10 mg/kg, i.p; q.d.). Arrests cell cycle at the G2/M phase and triggers protective autophagy and induces apoptosis by increasing the active forms of caspase 3, 7, and 9. Treatment of serum-starved MIA PaCa-2 cells with DPP-23 induces the phosphorylation of ERK1/2, JNK1/2, and p38 MAPK in a time-dependent manner.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₈H₁₈O₄
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesShin, Y.S., et al. 2014. Clin. Cancer Res. 20, in press.