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Description
Overview
A cell-permeable chalcone derivative that enhances the production of reactive oxygen species and reduces glutathione levels selectively in cancer cells while sparing normal cells and induces unfolded protein response (UPR) through up-regulating UPR related genes. Inhibits the growth of in multiple cancer cell lines (Capan-1, MDA-MB231, HCT116, and HT1080 cells) and suppresses the growth of HCT116 tumor xenografts in nude mice via the induction of apoptosis (10 mg/kg, i.p; q.d.). Arrests cell cycle at the G2/M phase and triggers protective autophagy and induces apoptosis by increasing the active forms of caspase 3, 7, and 9. Treatment of serum-starved MIA PaCa-2 cells with DPP-23 induces the phosphorylation of ERK1/2, JNK1/2, and p38 MAPK in a time-dependent manner.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number
531709
Brand Family
Calbiochem®
Synonyms
Unfolded Protein Response Inducer, DPP-23, UPR Inducer, DPP_23
References
References
Shin, Y.S., et al. 2014. Clin. Cancer Res.20, in press.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
19-December-2014 JSW
Synonyms
Unfolded Protein Response Inducer, DPP-23, UPR Inducer, DPP_23
Description
A cell-permeable chalcone derivative that enhances the production of reactive oxygen species and reduces glutathione levels selectively in cancer cells while sparing normal cells and induces unfolded protein response (UPR) through up-regulating UPR related genes. Inhibits the growth of in multiple cancer cell lines (Capan-1, MDA-MB231, HCT116, and HT1080 cells) and suppresses the growth of HCT116 tumor xenografts in nude mice via the induction of apoptosis (10 mg/kg, i.p; q.d.). Arrests cell cycle at the G2/M phase and triggers protective autophagy and induces apoptosis by increasing the active forms of caspase 3, 7, and 9. Treatment of serum-starved MIA PaCa-2 cells with DPP-23 induces the phosphorylation of ERK1/2, JNK1/2, and p38 MAPK in a time-dependent manner.
Form
Off-white solid
Intert gas (Yes/No)
Packaged under inert gas
Chemical formula
C₁₈H₁₈O₄
Purity
≥98% by HPLC
Solubility
DMSO (50 mg/ml)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Shin, Y.S., et al. 2014. Clin. Cancer Res.20, in press.