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MAB1681 Anti-Vimentin Antibody, clone LN-6

MAB1681
1 mL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MIH(P)MCulture SupernatantMonoclonal Antibody
      Description
      Catalogue NumberMAB1681
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Vimentin Antibody, clone LN-6
      Background InformationVimentin is a class III intermediate filament protein (homopolymers) found in various non-epithelial cells including mesenchymal cells and fibroblasts. In many cells of mesenchymal origin, it is one of the most prominent phosphoproteins, especially during cell division when enhanced phosphorylation of vimentin corresponds with the reorganization of vimentin filaments.
      References
      Product Information
      FormatCulture Supernatant
      Control
      • Hyperplastic lymph nodes.
      PresentationLiquid tissue culture supernatant containing 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Vimentin Antibody, clone LN-6 detects level of Vimentin & has been published & validated for use in IH(P).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry on B5 fixed, paraffin embedded tissue sections.
      Biological Information
      ImmunogenNuclei from adult human thymic biopsy specimens.
      CloneLN-6
      HostMouse
      SpecificityReacts with human mesenchymal cells and derived sarcomas. Reacts with an epitope of the cytoskeletal protein vimentin but unlike other vimentin antibodies, does not react with human lymphoid cells or derived malignancies. Reactive with endothelium, muscle, fibroblasts, melanocytes, peripheral nerve, sertoli cells, kidney mesangial cells and tubules, osteoblasts and periosteum, non-hematopoietic tumors of mesenchymal origin (all sarcomas), meningiomas and melanomas.
      IsotypeIgM
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryAlong with the microfilaments (actins) and microtubules (tubulins), the intermediate filaments represent a third class of well-characterized cytoskeletal elements. The subunits display a tissue-specific pattern of expression. Desmin (MIM 125660) is the subunit specific for muscle and vimentin the subunit specific for mesenchymal tissue.[supplied by OMIM]
      Gene Symbol
      • VIM
      • FLJ36605
      • Vimentin.
      • vimentin
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08670 # Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells.
      SIZE: 466 amino acids; 53652 Da
      SUBUNIT: Homopolymer. Component of a complex composed at least of ACTB, AP2M1, AP2A1, AP2A2, MEGF10 and VIM. Interacts with HCV core protein.
      TISSUE SPECIFICITY: Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone- independent mammary carcinoma cell lines.
      PTM: One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized.
      SIMILARITY: SwissProt: P08670 ## Belongs to the intermediate filament family.
      Molecular Weight57-60 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size1 mL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Vimentin Antibody, clone LN-6 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Vimentin Antibody, clone LN-6 Certificates of Analysis

      TitleLot Number
      MOUSE ANTI- VIMENTIN 3060464
      MOUSE ANTI- VIMENTIN MONOCLONAL ANTIBODY - 2420370 2420370
      MOUSE ANTI- VIMENTIN -2641681 2641681
      MOUSE ANTI- VIMENTIN -2657476 2657476
      MOUSE ANTI- VIMENTIN -2668121 2668121
      MOUSE ANTI- VIMENTIN MONOCLONAL ANTIBODY 3005316
      MOUSE ANTI- VIMENTIN MONOCLONAL ANTIBODY 3776790
      MOUSE ANTI- VIMENTIN MONOCLONAL ANTIBODY - 2293683 2293683

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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies