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MAB5504A4 Anti-Vesicular Glutamate Transporter 2 Antibody, Alexa Fluor® 488 | MAB5504A4

MAB5504A4
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, R, HIHCMAlexaFluor®488Monoclonal Antibody
      Description
      Catalogue NumberMAB5504A4
      DescriptionAnti-Vesicular Glutamate Transporter 2 Antibody, Alexa Fluor® 488 | MAB5504A4
      Alternate Names
      • Vesicular glutamate transporter 2
      • VGluT2
      • Differentiation-associated BNPI
      • Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter
      • Solute carrier family 17 member 6
      Background InformationVesicular Glutamate Transporter 2 (VGLUT2) is a sodium dependent inorganic phosphate cotransporter that is involved in the calcium dependent glutamate release from astrocytes. It is expressed in only a subset of neurons, localized to synaptic vesicles, at synapses exhibiting classical excitatory features. VGLUT2 mRNA is found in brain regions that lack VGLUT1, a related protein also displaying sodium dependent inorganic phosphate cotransporter activity.
      References
      Product Information
      FormatAlexaFluor®488
      Control
      • Adult mouse brain tissue
      PresentationPurified mouse monoclonal IgG1 conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Quality LevelMQ100
      Applications
      Key Applications
      • Immunohistochemistry
      Biological Information
      ImmunogenRecombinant protein from rat VGLUT2.
      Clone8G9.2
      HostMouse
      IsotypeIgG1
      Species Reactivity
      • Mouse
      • Rat
      • Human
      Species Reactivity NoteDemonstrated to react with Mouse and Rat. Predicted to react with Human based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryNa+-dependent inorganic phosphate cotransporter; involved in Ca2+-dependent glutamate release from astrocytes [RGD].
      Gene Symbol
      • Slc17a6
      • Dnpi
      • Vglut2
      • VGLUT2
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas. May also mediate the transport of inorganic phosphate.

      SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome.

      TISSUE SPECIFICITY: Expressed in brain (at protein level). Expressed in brainstem, deep nuclei, septal nuclei, nuclei of the diagonal band, frontal cortex, hypothalamus, midbrain, parietal cortex and temporal cortex. Also expressed in pineal gland and islets of Langerhans.

      SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.

      SIZE: 582 amino acids; 64392 Da
      Molecular WeightThe unconjugated parent antibody (Cat. No. MAB5504) has an observed molecular weight at ~56 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in adult mouse brain tissue.

      Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Vesicular Glutamate Transporter 2 in adult mouse brain tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Vesicular Glutamate Transporter 2 Antibody, Alexa Fluor® 488 | MAB5504A4 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Vesicular Glutamate Transporter 2 Antibody, Alexa Fluor® 488 | MAB5504A4 Certificates of Analysis

      TitleLot Number
      Anti-Vesicular Glutamate Transporter -2643641 2643641
      Anti-Vesicular Glutamate Transporter 2, Alexa Fluor#174; 488 Conjugate - NRG1922541 NRG1922541
      Anti-Vesicular Glutamate Transporter 2, Alexa Fluor® 488 Conjugate 2967898
      Anti-Vesicular Glutamate Transporter 2, Alexa Fluor® 488 Conjugate 3113928
      Anti-Vesicular Glutamate Transporter 2, Alexa Fluor® 488 Conjugate 3008422
      Anti-Vesicular Glutamate Transporter 2, Alexa Fluor® 488 Conjugate 3557959
      Anti-Vesicular Glutamate Transporter 2, Alexa Fluor® 488 Conjugate - 2377644 2377644
      Anti-Vesicular Glutamate Transporter 2, Alexa Fluor® 488 Conjugate - 3164883 3164883
      Anti-Vesicular Glutamate Transporter 2, Alexa Fluor® 488 Conjugate - 3251480 3251480
      Anti-Vesicular Glutamate Transporter 2, Alexa Fluor® 488 Conjugate - 3329597 3329597

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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies