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36-009 Anti-β-Synuclein Antibody, clone Syn207

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36-009
200 µL  
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Overview

Replacement Information

Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWB, IHCMAscitesMonoclonal Antibody
Description
Catalogue Number36-009
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-β-Synuclein Antibody, clone Syn207
References
Product Information
FormatAscites
Presentationascites with 0.05% sodium azide
Quality LevelMQ100
Applications
ApplicationAnti-β-Synuclein Antibody, clone Syn207 is an antibody against β-Synuclein for use in WB, IH.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Biological Information
Immunogenfull length recombinant human β-Synuclein
Cloneclone Syn207
HostMouse
Specificityrecombinant β-Synuclein
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene.
Gene Symbol
  • SNCB
  • beta-synuclein
  • Beta-synuclein.
Purification MethodAscites
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q16143 # Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6 hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
SIZE: 134 amino acids; 14288 Da
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
PTM: Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
DISEASE: SwissProt: Q16143 # Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCB is found in spheroids but not in inclusions.
SIMILARITY: SwissProt: Q16143 ## Belongs to the synuclein family.
Molecular Weight~17kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assuranceroutinely evaluated by immunoblot lot detected β-Synuclein recombinant protein
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions2 years at -20°C
Packaging Information
Material Size200 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
36-009 04053252371936

Documentation

Anti-β-Synuclein Antibody, clone Syn207 SDS

Title

Safety Data Sheet (SDS) 

Anti-β-Synuclein Antibody, clone Syn207 Certificates of Analysis

TitleLot Number
Anti-#946;-Synuclein, clone Syn207 (mouse ascites) - 2141824 2141824
Anti-B-Synuclein, clone Syn207 (mouse ascites) 2894700
Anti-b-Synuclein, clone Syn207 (mouse ascites) - 1999454 1999454
Anti-b-Synuclein, clone Syn207 (mouse ascites) - 2011458 2011458
Anti-b-Synuclein, clone Syn207 (mouse ascites) - 2110003 2110003
Anti-b-Synuclein, clone Syn207 - DAM18177125 DAM18177125
Anti-b-Synuclein, clone Syn207 - NG1896098 NG1896098
Anti-beta;-Synuclein, clone Syn207 - 26829 26829
Anti-ß-Synuclein, clone Syn207 -2858446 2858446
Anti-β-Synuclein, clone Syn207 (mouse ascites) - 2391417 2391417

References

Reference overviewApplicationPub Med ID
Localization of synucleins in the mammalian cochlea.
Akil, O; Weber, CM; Park, SN; Ninkina, N; Buchman, V; Lustig, LR
Journal of the Association for Research in Otolaryngology : JARO  9  452-63  2008

Show Abstract Full Text Article
18665422 18665422
Oxidative stress and nitration in neurodegeneration: cause, effect, or association?
Ischiropoulos, Harry and Beckman, Joseph S
J. Clin. Invest., 111: 163-9 (2003)  2003

12531868 12531868
Alpha-synuclein: its biological function and role in neurodegenerative diseases.
Kaplan, Batia, et al.
J. Mol. Neurosci., 20: 83-92 (2003)  2003

Show Abstract
12794302 12794302
Oxidative modifications of alpha-synuclein.
Ischiropoulos, Harry
Ann. N. Y. Acad. Sci., 991: 93-100 (2003)  2003

Show Abstract
12846977 12846977
Development of new treatments for Parkinson's disease in transgenic animal models: a role for beta-synuclein.
Masliah, Eliezer and Hashimoto, Makoto
Neurotoxicology, 23: 461-8 (2002)  2002

Show Abstract
12428718 12428718
A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease
Giasson, B. I., et al
J Neurosci Res, 59:528-33 (2000)  2000

Immunoblotting (Western), Immunohistochemistry (Tissue)10679792 10679792
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.
Tu, P H, et al.
Ann. Neurol., 44: 415-22 (1998)  1998

Show Abstract
Immunoblotting (Western)9749615 9749615