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04-035 Anti-PTEN Antibody, clone 6H2.1

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100 µg  
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Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWB, IP, IH(P)MPurifiedMonoclonal Antibody
Catalogue Number04-035
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-PTEN Antibody, clone 6H2.1
Background InformationThe protein and lipid phosphatase PTEN (phosphatase and tensin homolog deleted on chromosome ten) has been suggested to play a role in tumorgenesis. PTEN is a tumor suppressor whose loss permits constitutive signaling through the PI3K pathway and is sufficient to cause cancer. In normal cells, in conjunction with FOXO1A and PTEN function together to restrain cell growth. PTEN metabolizes the product of PI3K phosphorylation of PI(4,5)P2 following receptor activation, creating PI(3,4,5)P3. In cells lacking PTEN, there are elevated levels of PI(3,4,5)P3, which acts as a potent second messenger promoting oncogenesis. Restoration of PTEN function is considered a novel approach to cancer therapy. Overexpression of PTEN inhibits cell migration, and expression of antisense PTEN mRNA enhances migration.
Product Information
PresentationPurified mouse IgG in storage buffer containing 0.1M Tris-Glycine, 0.15M NaCl, pH 7.4, with 0.05% sodium azide.
Quality LevelMQ100
ApplicationAnti-PTEN Antibody, clone 6H2.1 detects level of PTEN & has been published & validated for use in WB, IP, IH(P).
Key Applications
  • Western Blotting
  • Immunoprecipitation
  • Immunohistochemistry (Paraffin)
Biological Information
ImmunogenC-terminal 100 amino acids of PTEN
EpitopeC-terminal region
Specificityrecognizes PTEN
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • PTEN
  • MMAC1
  • TEP1
Purification MethodProtein G Purified
UniProt Number
Molecular Weight55 kDa
Physicochemical Information
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assuranceroutinely evaluated on HeLa cell lysate
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Global Trade Item Number
Catalog Number GTIN
04-035 04053252366475


Anti-PTEN Antibody, clone 6H2.1 Certificates of Analysis

TitleLot Number
Anti-IL-2 Receptor , clone 7G7/B6 -2775434 2775434
Anti-PTEN, clone 6H2.1 - 2424483 2424483
Anti-PTEN, clone 6H2.1 - 2455715 2455715
Anti-PTEN, clone 6H2.1 - 1993873 1993873
Anti-PTEN, clone 6H2.1 - 2038721 2038721
Anti-PTEN, clone 6H2.1 - 2073180 2073180
Anti-PTEN, clone 6H2.1 - 2189937 2189937
Anti-PTEN, clone 6H2.1 - 2329127 2329127
Anti-PTEN, clone 6H2.1 - 3179917 3179917
Anti-PTEN, clone 6H2.1 - 3542481 3542481


Reference overviewApplicationPub Med ID
PTEN signaling is required for the maintenance of spermatogonial stem cells in mouse, by regulating the expressions of PLZF and UTF1.
Zhou, W; Shao, H; Zhang, D; Dong, J; Cheng, W; Wang, L; Teng, Y; Yu, Z
Cell & bioscience  5  42  2015

Show Abstract
26221533 26221533
Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development.
Jones, A; Teschendorff, AE; Li, Q; Hayward, JD; Kannan, A; Mould, T; West, J; Zikan, M; Cibula, D; Fiegl, H; Lee, SH; Wik, E; Hadwin, R; Arora, R; Lemech, C; Turunen, H; Pakarinen, P; Jacobs, IJ; Salvesen, HB; Bagchi, MK; Bagchi, IC; Widschwendter, M
PLoS medicine  10  e1001551  2013

Show Abstract
24265601 24265601
Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior.
Anastasio, NC; Gilbertson, SR; Bubar, MJ; Agarkov, A; Stutz, SJ; Jeng, Y; Bremer, NM; Smith, TD; Fox, RG; Swinford, SE; Seitz, PK; Charendoff, MN; Craft, JW; Laezza, FM; Watson, CS; Briggs, JM; Cunningham, KA
The Journal of neuroscience : the official journal of the Society for Neuroscience  33  1615-30  2013

Show Abstract
23345234 23345234
BRCAness profile of sporadic ovarian cancer predicts disease recurrence.
Wysham, WZ; Mhawech-Fauceglia, P; Li, H; Hays, L; Syriac, S; Skrepnik, T; Wright, J; Pande, N; Hoatlin, M; Pejovic, T
PloS one  7  e30042  2012

Show Abstract
Immunocytochemistry22253870 22253870
Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity.
Baker, DJ; Jin, F; Jeganathan, KB; van Deursen, JM
Cancer cell  16  475-86  2009

Show Abstract
Immunohistochemistry19962666 19962666