Millipore Sigma Vibrant Logo

07-276 Anti-PDGFRα Antibody

07-276
200 µL  
Retrieving price...
Price could not be retrieved
Minimum Quantity is a multiple of
Maximum Quantity is
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MIP, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-276
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-PDGFRα Antibody
      Background InformationPlatelet derived growth factor receptor (PDGF Receptor) is a transmembrane glycoprotein of 170-185 kDa which undergoes homo or heterodimerization into complexes of alpha and beta subunits upon ligand binding, depending on the isoform of PDGF (PDGF AA, BB or AB) that binds. The phosphorylation of tyrosine residues in the now activated receptor can control multiple signaling events such as actin reorganization, transcription, cell growth, migration and differentiation, and also lead to activation of the Ras, Raf and ERK 1 and 2 pathway.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HeLa cells, extracts from 3T3/NIH or HepG2 cells, human brain tissue
      PresentationProtein A Purified immunoglobulin in 0.14 M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
      Quality LevelMQ100
      Applications
      ApplicationDetect PDGFRα using this Anti-PDGFRα Antibody validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      Immunogenpeptide corresponding to amino acids 1035-1053 (C-GKRNRHSSQTSEESAIETG) of human PDGF Receptor α
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes PDGF Receptor alpha.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
      Gene Symbol
      • PDGFRA
      • CD140a
      • PDGF-R-alpha
      • MGC74795
      • PDGFR2
      • Rhe-PDGFRA
      • CD140A
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P16234 # Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
      SIZE: 1089 amino acids; 122670 Da
      SUBUNIT: Homodimer, and heterodimer with PDGFRB. Interacts with SHB (By similarity).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      DISEASE: SwissProt: P16234 # A fusion of PDGFRA and FIP1L1 (FIP1L1-PDGFRA), due to an interstitial chromosomal deletion, is the cause of some cases of hypereosinophilic syndrome (HES) [MIM:607685]. HES is a rare hematologic disorder characterized by sustained overproduction of eosinophils in the bone marrow, eosinophilia, tissue infiltration and organ damage.
      SIMILARITY: SwissProt: P16234 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
      Molecular Weight150/170 kDa (doublet)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on 3T3/NIH cell lysate
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-PDGFRα Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-PDGFRα Antibody Certificates of Analysis

      TitleLot Number
      Anti-CHD-1 -2818704 2818704
      Anti-PDGF Receptor a (rabbit immunoaffinity purified IgG) Q2922346
      Anti-PDGFRa (rabbit immunoaffinity purified IgG) 2897148
      Anti-PDGFRa (rabbit immunoaffinity purified IgG) - 2193158 2193158
      Anti-PDGFRa (rabbit immunoaffinity purified IgG) - 2377380 2377380
      Anti-PDGFRa (rabbit immunoaffinity purified IgG) - JBC1922553 JBC1922553
      Anti-PDGFRa - 2073123 2073123
      Anti-PDGFRalpha; - 22127 22127
      Anti-PDGFRalpha; - 24835 24835
      Anti-PDGFRalpha; - 30083 30083

      References

      Reference overviewApplicationPub Med ID
      Enhanced transduction and replication of rGD-fiber Modified adenovirus in primary t cells.
      Sengupta S, Ulasov IV, Thaci B, Ahmed AU, Lesniak MS
      PloS one  6  e18091.  2011

      Full Text Article
      21464908 21464908
      Mesenchymal stem cells modified with a single-chain antibody against EGFRvIII successfully inhibit the growth of human xenograft malignant glioma.
      Balyasnikova IV, Ferguson SD, Sengupta S, Han Y, Lesniak MS
      PLoS One  5  e9750  2010

      Show Abstract Full Text Article
      20305783 20305783
      MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis.
      Eberhart, JK; He, X; Swartz, ME; Yan, YL; Song, H; Boling, TC; Kunerth, AK; Walker, MB; Kimmel, CB; Postlethwait, JH
      Nature genetics  40  290-8  2008

      Show Abstract Full Text Article
      18264099 18264099
      PDGF- and insulin/IGF-1-specific distinct modes of class IA PI 3-kinase activation in normal rat retinas and RGC-5 retinal ganglion cells.
      Biswas, SK; Zhao, Y; Nagalingam, A; Gardner, TW; Sandirasegarane, L
      Investigative ophthalmology & visual science  49  3687-98  2008

      Show Abstract
      18421086 18421086
      The novel tyrosine kinase inhibitor EXEL-0862 induces apoptosis in human FIP1L1-PDGFR-alpha-expressing cells through caspase-3-mediated cleavage of Mcl-1.
      Pan, J; Quintás-Cardama, A; Manshouri, T; Giles, FJ; Lamb, P; Tefferi, A; Cortes, J; Kantarjian, H; Verstovsek, S
      Leukemia  21  1395-404  2007

      Show Abstract
      17495975 17495975
      Evidence for PDGFRA, PDGFRB and KIT deregulation in an NSCLC patient.
      Negri, T; Casieri, P; Miselli, F; Orsenigo, M; Piacenza, C; Stacchiotti, S; Bidoli, P; Casali, PG; Pierotti, MA; Tamborini, E; Pilotti, S
      British journal of cancer  96  180-1  2007

      Show Abstract
      Immunoprecipitation17213828 17213828
      Activity of AMN107, a novel aminopyrimidine tyrosine kinase inhibitor, against human FIP1L1-PDGFR-alpha-expressing cells.
      Srdan Verstovsek, Francis J Giles, Alfonso Quintás-Cardama, Taghi Manshouri, Ly Huynh, Paul Manley, Jorge Cortes, Ayalew Tefferi, Hagop Kantarjian
      Leukemia research  30  1499-505  2006

      Show Abstract
      16682077 16682077
      Lack of clinical efficacy of imatinib in metastatic melanoma.
      Ugurel, S; Hildenbrand, R; Zimpfer, A; La Rosée, P; Paschka, P; Sucker, A; Keikavoussi, P; Becker, JC; Rittgen, W; Hochhaus, A; Schadendorf, D
      British journal of cancer  92  1398-405  2005

      Show Abstract Full Text Article
      15846297 15846297

      Related Products & Applications

      Related Products

      Catalog Number Description  
      CBL1366 Anti-CD140a Antibody, clone APA5 Show Pricing & Availability

      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies