AB2282 Anti-Neuropeptide S Antibody

AB2282
50 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, M, H IHC Rb Purified Polyclonal Antibody
      Description
      Catalogue NumberAB2282
      DescriptionAnti-Neuropeptide S Antibody
      Alternate Names
      • neuropeptide S
      Background InformationNeuropeptide S (NPS) is in the neurobiology of sleep/wakefulness regulation and anxiety-like behavior. NPS activates NPS receptors to increase concentrations of intracellular Ca(2+). Anatomically, both NPS precursor and receptor mRNAs are found predominately in the central nervous system. NPS precursor mRNA is expressed only in several discrete regions located mainly in the brainstem. In particular, it is highly expressed in a previously undescribed group of neurons localized between locus coeruleus and Barrington's nucleus. NPS also significantly increases wakefulness and decreases paradoxical (rapid eye movement) sleep and slow wave sleep in rats. In addition, NPS suppresses anxiety-like behaviors in mice exposed to different behavioral paradigms measuring responses to novelty or stress (1).
      References
      Product Information
      FormatPurified
      Control
      • Rat Brain (Cerebellum).
      PresentationPurified in 0.1M Tris-Glycine (pH7.4) 15mM NaCl with 0.05% NaN3
      Applications
      ApplicationAnti-Neuropeptide S Antibody is an antibody against Neuropeptide S for use in IH.
      Key Applications
      • Immunohistochemistry
      Applications Not Recommended
      • Western Blotting
      Biological Information
      ImmunogenSynthetic Linear Peptide
      EpitopeMature Peptide (After Cleavage)
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityCat. # AB2282 recognizes Neuropeptide S in tissue.
      Species Reactivity
      • Rat
      • Mouse
      • Human
      Species Reactivity NoteRat. May react with mouse and human based on sequence homology. Reactivity with other species has not been tested.
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • NPS
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFunction: May play an important anorexigenic role. Modulates arousal and anxiety as well as increases locomotor activity.
      Subcellular location: Secreted.
      Tissue specificity: Expressed in mammary, salivary and thyroid gland. Expressed in the brain, in a cluster of cells located between the locus coeruleus (LC) and Barrington's nucleus, as well as in few cells of the dorsomedial hypothalamic nucleus and the amygdala.
      Molecular Weight~10 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunohistochemistry in rat brain.

      Antibody diluted to 1:100
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation