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AB5864 Anti-Myelin Basic Protein Antibody

AB5864
50 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RIHCRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB5864
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Myelin Basic Protein Antibody
      Alternate Names
      • MBP
      References
      Product Information
      FormatSerum
      Control
      • Brain tissue
      PresentationRabbit Serum. Lyophilized, no preservatives. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any residue.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Myelin Basic Protein Antibody is an antibody against Myelin Basic Protein for use in IH.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1:2,000. Immunostains myelin basic protein of abnormal appearing oligodendrocytic processes and cell bodies in demyelinating areas. The antibody recognizes only areas of myelin degeneration when tested in injured spinal cord and lesioned sciatic nerve. It also stains discrete white matter in brain of multiple system atrophy

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to amino acids 69-86 of the guinea pig protein. Immunogen corresponds to "degraded" Myelin Basic Protein: YGSLPQKSQRSQDENPVV
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes Myelin Basic Protein in demyelinated nerve tissues. Immunohistochemistry analysis of lesioned rat spinal cord shows a high level of specificity for this antiserum.
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
      Gene Symbol
      • MBP
      • MGC99675
      • Golli-mbp
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).
      SIZE: 167 amino acids; 18213 Da
      SUBUNIT: Homodimer
      TISSUE SPECIFICITY: Found in both the central and the peripheral nervous system.
      PTM: At least 5 charge isomers; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4 and C5 (the least cationic form); are produced as a result of optional post-translational modifications such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues. C1 and C2 are unphosphorylated, C3 and C4 are monophosphorylated and C5 is phosphorylated at two positions (PubMed: 51849)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20 to -70°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Myelin Basic Protein Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Myelin Basic Protein Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-MYELIN BASIC PROTEIN POLYCLONAL ANTIBODY - 2122407 2122407
      RABBIT ANTI-MYELIN BASIC PROTEIN POLYCLONAL ANTIBODY - 2127751 2127751
      RABBIT ANTI-MYELIN BASIC PROTEIN POLYCLONAL ANTIBODY - 2138543 2138543
      RABBIT ANTI-MYELIN BASIC PROTEIN POLYCLONAL ANTIBODY - 2382586 2382586
      RABBIT ANTI-MYELIN BASIC PROTEIN POLYCLONAL ANTIBODY - 2392237 2392237
      RABBIT ANTI-MYELIN BASIC PROTEIN POLYCLONAL ANTIBODY - 2420333 2420333
      RABBIT ANTI-MYELIN BASIC PROTEIN POLYCLONAL ANTIBODY - 2424619 2424619
      RABBIT ANTI-MYELIN BASIC PROTEIN POLYCLONAL ANTIBODY - 2446703 2446703
      RABBIT ANTI-MYELIN BASIC PROTEIN POLYCLONAL ANTIBODY - 2024199 2024199
      RABBIT ANTI-MYELIN BASIC PROTEIN - 2558410 2558410

      Data Sheet

      Title
      RABBIT ANTI-MYELIN BASIC PROTEIN

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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies