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MAB1567 Anti-Myelin Associated Glycoprotein Antibody, clone 513

MAB1567
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, Ch, H, M, R, FgICC, IHC, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB1567
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Myelin Associated Glycoprotein Antibody, clone 513
      Alternate Names
      • MAG
      Background InformationMyelin-associated glycoprotein (MAG),a member of the immunoglobulin superfamily, is a membrane glycoprotein of 100 kDa, and is thought to be involved in the process of myelination. Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and MAG. MAG has been implicated in the inhibition of nerve regeneration in the CNS.
      References
      Product Information
      FormatPurified
      Control
      • Rat hippocampus tissue, rat brain lysate, PC12 cells.
      PresentationPurified mouse monoclonal IgG1 in buffer containing 10 mM potassium phosphate buffer, 50 mM NaCl, pH 7.5. Contains no preservative.
      Quality LevelMQ100
      Applications
      ApplicationDetect Myelin Associated Glycoprotein using this Anti-Myelin Associated Glycoprotein Antibody, clone 513 validated for use in IC, IH & WB.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern Blot:
      20 μg/mL of a previous lot was used on western blot under non-reducing conditions only.{See Ellezam, 2003}

      Immunocytochemistry:
      5-10 µg/mL of a previous lot was used, methanol fixation required.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenL2 epitope carrying glycoprotein extract of 1-2 day old chicken brain.
      Clone513
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityDetects Myelin Associated Glycoprotein (MAG) in immunohistochemistry on frozen sections, immunocytochemistry and Western blot (under non-reducing conditions). MAB1567 is useful for myelinogenesis and multiple sclerosis studies.
      IsotypeIgG1
      Species Reactivity
      • Bovine
      • Chicken
      • Human
      • Mouse
      • Rat
      • Frog
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
      Gene Symbol
      • MAG
      • SIGLEC4A
      • SIGLEC-4A
      • Siglec-4a
      • S-MAG
      • GMA
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P20916 # Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha2,3- linked sialic acid (By similarity).
      SIZE: 626 amino acids; 69069 Da
      SUBUNIT: Binds to RTN4R (By similarity).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P20916 ## Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. & Contains 4 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 Ig-like V-type (immunoglobulin-like) domain.
      Molecular Weight100 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by immunohistochemistry on rat hippocampus.

      Immunohistochemistry(paraffin):
      Representative image from a previous lot.
      Mouse anti-Myelin Associated Glycoprotein [MAG] (Catalog Number MAB1567) localization of MAG in rat hippocampus. Photo courtesy of Dr. Robert Sloviter, University of Arizona.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20ºC from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Myelin Associated Glycoprotein Antibody, clone 513 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Myelin Associated Glycoprotein Antibody, clone 513 Certificates of Analysis

      TitleLot Number
      Anti-Myelin Associated Glycoprotein, -2571193 2571193
      Anti-Myelin Associated Glycoprotein, clone 513 2475755
      Anti-Myelin Associated Glycoprotein, clone 513 - 2343575 2343575
      Anti-Myelin Associated Glycoprotein, clone 513 - 2378014 2378014
      Anti-Myelin Associated Glycoprotein, clone 513 - 2444138 2444138
      Anti-Myelin Associated Glycoprotein, clone 513 - 1959590 1959590
      Anti-Myelin Associated Glycoprotein, clone 513 - 2004536 2004536
      Anti-Myelin Associated Glycoprotein, clone 513 - 2049796 2049796
      Anti-Myelin Associated Glycoprotein, clone 513 - 2167150 2167150
      Anti-Myelin Associated Glycoprotein, clone 513 - 2277843 2277843

      Related Products & Applications

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      Catalog Number Description  
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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies