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407286 Anti-Integrin αv (Ab-1) Mouse mAb (272-17E6)

407286
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Overview

Replacement Information

Key Specifications Table

Species ReactivityHostAntibody Type
H M Monoclonal Antibody

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407286-100UG
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      Plastic ampoule 100 μg
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      Description
      OverviewRecognizes the αv integrin chain and all αv-containing integrins.
      Catalogue Number407286
      Brand Family Calbiochem®
      SynonymsAnti-CD51
      References
      ReferencesAkiyama, S.K. 1996. Hum. Cell 9, 181.
      Hynes, R.O. 1992. Cell 69, 11.
      Albelda, S.M. and Buck, C.A. 1990. FASEB J. 4, 2868.
      Buck, C.A. and Horwitz, A.F. 1987. Ann. Rev. Cell Biol. 3, 179.
      Hynes, R.O. 1987. Cell 45, 549.
      Product Information
      FormLiquid
      FormulationIn PBS, pH 7.6.
      Preservative≤0.1% sodium azide
      Quality LevelMQ100
      Applications
      Application ReferencesCell Inhibition Assays, ELISA, Flow Cytometry, and Immunoprecipitation Mitjans, F., et al. 1995 J. Cell Sci. 108, 2825.
      Key Applications Immunoprecipitation
      Cell Inhibition Assays
      Enzyme-Linked Immunosorbent Assay
      Flow Cytometry
      Application NotesCell Inhibition Assays (see application reference)
      ELISA (see application reference)
      Flow Cytometry (2.5 µg/ml, see application reference)
      Immunoprecipitation (2.5 µg/ml, see application reference)
      Application CommentsCross-reacts with all αv integrins. Blocks cell adhesion mediated by all αv integrins and in vivo melanoma growth and angiogenesis (see application references). Variables associated with assay conditions will dictate the proper working dilution.
      Biological Information
      Immunogenhuman placental αvβ₃ integrin
      ImmunogenHuman
      Clone272-17E6
      HostMouse
      IsotypeIgG₁
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Integrin αv (Ab-1) Mouse mAb (272-17E6) SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Integrin αv (Ab-1) Mouse mAb (272-17E6) Certificates of Analysis

      TitleLot Number
      407286

      References

      Reference overview
      Akiyama, S.K. 1996. Hum. Cell 9, 181.
      Hynes, R.O. 1992. Cell 69, 11.
      Albelda, S.M. and Buck, C.A. 1990. FASEB J. 4, 2868.
      Buck, C.A. and Horwitz, A.F. 1987. Ann. Rev. Cell Biol. 3, 179.
      Hynes, R.O. 1987. Cell 45, 549.

      Brochure

      Title
      The Active Siteル Volume 4, Number 1
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-April-2012 JSW
      SynonymsAnti-CD51
      ApplicationCell Inhibition Assays (see application reference)
      ELISA (see application reference)
      Flow Cytometry (2.5 µg/ml, see application reference)
      Immunoprecipitation (2.5 µg/ml, see application reference)
      DescriptionPurified mouse monoclonal antibody. Recognizes the αv integrin chain and all αv-containing integrins.
      BackgroundThe integrins are a family of more than 23 heterodimeric transmembrane proteins that mediate cell-cell adhesions as well as cell-substratum adhesions and signal transduction processes. Integrins are heterodimers consisting of noncovalently associated α and β subunits. Human CD51 is an integrin alpha v chain which can associate with five different beta chains (β1, β3, β5, β6, and β8) to form various adhesion molecules. CD51 is found in endothelial cells, smooth muscle cells, fibroblasts, mast cells, monocytes, osteoclasts, platelets, and melanoma cells.
      HostMouse
      Immunogen speciesHuman
      Immunogenhuman placental αvβ₃ integrin
      Clone272-17E6
      IsotypeIgG₁
      Specieshuman
      FormLiquid
      FormulationIn PBS, pH 7.6.
      Concentration Label Please refer to vial label for lot-specific concentration
      Preservative≤0.1% sodium azide
      CommentsCross-reacts with all αv integrins. Blocks cell adhesion mediated by all αv integrins and in vivo melanoma growth and angiogenesis (see application references). Variables associated with assay conditions will dictate the proper working dilution.
      Storage -20°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesAkiyama, S.K. 1996. Hum. Cell 9, 181.
      Hynes, R.O. 1992. Cell 69, 11.
      Albelda, S.M. and Buck, C.A. 1990. FASEB J. 4, 2868.
      Buck, C.A. and Horwitz, A.F. 1987. Ann. Rev. Cell Biol. 3, 179.
      Hynes, R.O. 1987. Cell 45, 549.
      Application referencesCell Inhibition Assays, ELISA, Flow Cytometry, and Immunoprecipitation Mitjans, F., et al. 1995 J. Cell Sci. 108, 2825.