07-104 Anti-IGF2 mRNA-binding protein 3 Antibody

07-104
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, Chp, Ca, Eq WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue Number07-104
      DescriptionAnti-IGF2 mRNA-binding protein 3 Antibody
      Alternate Names
      • IGF II mRNA binding protein 3
      • IGF-II mRNA-binding protein 3
      • IGF2 mRNA-binding protein 3
      • KH domain containing protein overexpressed in cancer
      • KH domain-containing protein overexpressed in cancer
      • VICKZ family member 3
      • insulin-like growth factor 2 mRNA binding protein 3
      Background InformationThe protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor 2 leader 3 mRNA and may repress translation of insulin-like growth factor 2 during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq].
      References
      Product Information
      FormatAffinity Purified
      Control
      • Hek293 cell lysate
      PresentationPurified rabbit serum in PBS with 0.09% azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-IGF2 mRNA-binding protein 3 Antibody is validated for use in WB for the detection of IGF2 mRNA-binding protein 3.
      Key Applications
      • Western Blotting
      Application NotesWestern Blot (SNAP ID) Analysis: 2 µg/mL from a previous lot detected IGF2 mRNA-binding protein 3 on 10 µg of Hek293 cell lysate.

      Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human IGF2 mRNA-binding protein 3 at and around the C-terminus.
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes IGF2 mRNA-binding protein 3 at the C-terminus.
      Species Reactivity
      • Human
      • Mouse
      • Chimpanzee
      • Canine
      • Horse
      Species Reactivity NoteReacts with human and mouse. Predicted to react with chimpanzee, Rhesus monkey, dog, and horse based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor 2 leader 3 mRNA and may repress translation of insulin-like growth factor 2 during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq].
      Gene Symbol
      • IMP-3
      • IMP3
      • KOC1
      • VICKZ3
      • hKOC
      • IGF2BP3
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: RNA-binding protein that act as a regulator of mRNA translation and stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binds to sequences in the 3'-UTR of CD44 mRNA.

      SUBUNIT STRUCTURE: Homodimer and multimer.

      SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules.

      TISSUE SPECIFICITY: Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines.

      INVOLVEMENT IN DISEASE: Autoantibodies against IGF2BP3 are detected in sera from some patients with a variety of carcinomas.

      SEQUENCE SIMILARITIES: Belongs to the RRM IMP/VICKZ family.

      Contains 4 KH domains.

      Contains 2 RRM (RNA recognition motif) domains.
      Molecular Weight64 kDa was observed. Predicted to cross-react with all the Isoforms of IGF2BP3.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in Hek293 cell lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected IGF2 mRNA-binding protein 3 on 10 µg of Hek293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-IGF2 mRNA-binding protein 3 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-IGF2 mRNA-binding protein 3 Antibody Certificates of Analysis

      TitleLot Number
      Anti-IGF2 mRNA-binding protein 3 - 23817822381782
      Anti-IGF2 mRNA-binding protein 3 - 24414542441454
      Anti-IGF2 mRNA-binding protein 3 - 24459662445966
      Anti-IGF2 mRNA-binding protein 3 - 23092082309208
      Anti-IGF2 mRNA-binding protein 3 - 24927772492777
      Anti-IGF2 mRNA-binding protein 3 - 31991963199196
      Anti-IGF2 mRNA-binding protein 3 - NRG1665149NRG1665149
      Anti-IGF2 mRNA-binding protein 3 - NRG1665720NRG1665720
      Anti-IGF2 mRNA-binding protein 3 -28036662803666
      Anti-IGF2 mRNA-binding protein 3 -28239532823953

      References

      Reference overviewPub Med ID
      Insulin receptor substrate-2 regulates aerobic glycolysis in mouse mammary tumor cells via glucose transporter 1.
      Shannon L Pankratz,Ernest Y Tan,Yumiko Fine,Arthur M Mercurio,Leslie M Shaw
      The Journal of biological chemistry  284  2009

      Show Abstract Full Text Article
      19056742 19056742

      Technical Info

      Title
      Protein Blotting Handbook: 6th Edition (MilliporeSigma)

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies