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MAB3402X Anti-Glial Fibrillary Acidic Protein Antibody, clone GA5, Alexa Fluor® 488

MAB3402X
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Ch, H, Po, RICC, IHCMAlexaFluor®488Monoclonal Antibody
      Description
      Catalogue NumberMAB3402X
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Glial Fibrillary Acidic Protein Antibody, clone GA5, Alexa Fluor® 488
      Alternate Names
      • GFAP
      References
      Product Information
      FormatAlexaFluor®488
      PresentationPurified immunoglobulin conjugated to Alexa Fluor® 488. Liquid in Phosphate buffer with 15 mg/mL BSA as a stabilizer and 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Glial Fibrillary Acidic Protein using this Anti-Glial Fibrillary Acidic Protein Antibody, clone GA5, Alexa Fluor 488 validated for use in IC, IH.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      Application NotesImmunocytochemistry

      Immunohistochemistry

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenPurified glial filament (1).
      Cloneclone GA5
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThe antibody reacts with GFAP from human, pig, chicken and rat. In tissue sections this antibody stains astrocytes and Bergman glia cells (1).
      IsotypeIgG1
      Species Reactivity
      • Chicken
      • Human
      • Pig
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant has been described, but its full length sequence has not been determined.
      Gene Symbol
      • GFAP
      • FLJ45472
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P14136 # GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
      SIZE: 432 amino acids; 49880 Da
      SUBUNIT: Isoform 3 interacts with N-terminus of PSEN1.
      SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with intermediate filaments.
      DISEASE: SwissProt: P14136 # Defects in GFAP are a cause of Alexander disease [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.
      SIMILARITY: SwissProt: P14136 ## Belongs to the intermediate filament family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in the dark for up to 6 months after date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Glial Fibrillary Acidic Protein Antibody, clone GA5, Alexa Fluor® 488 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Glial Fibrillary Acidic Protein Antibody, clone GA5, Alexa Fluor® 488 Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) ALEXA FLUOR#63194;488 CONJUGATED MONOCLONAL ANTIBODY - 2118945 2118945
      MOUSE ANTI-GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) ALEXA FLUOR 488 CONJUGATED MONOCLONAL ANTIBODY - 2382622 2382622
      MOUSE ANTI-GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) ALEXA FLUOR488 CONJUGATED MONOCLONAL ANTIBODY - 2441941 2441941
      MOUSE ANTI-GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) - 3215524 3215524
      MOUSE ANTI-GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) - 3781102 3781102
      MOUSE ANTI-GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) -2517923 2517923
      MOUSE ANTI-GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) -2584862 2584862
      MOUSE ANTI-GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) -2646949 2646949
      MOUSE ANTI-GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) -2697567 2697567
      MOUSE ANTI-GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) -2759756 2759756

      References

      Reference overviewPub Med ID
      Glial reactivity in resistance to methamphetamine-induced neurotoxicity.
      Friend, DM; Keefe, KA
      Journal of neurochemistry  125  566-74  2013

      Show Abstract
      23414433 23414433
      Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction.
      Shihui Xing,Yusheng Zhang,Jingjing Li,Jian Zhang,Yiliang Li,Chao Dang,Chuo Li,Yuhua Fan,Jian Yu,Zhong Pei,Jinsheng Zeng
      Autophagy  8  2012

      Show Abstract
      22108007 22108007
      Infection of human astrocytoma cells with simian-human immunodeficiency virus results in up-regulation of gene expression and altered growth properties.
      Singh, Dinesh K, et al.
      Neurosci. Lett., 340: 201-4 (2003)  2003

      Show Abstract
      12672541 12672541
      Pathogenic and nef-interrupted simian-human immunodeficiency viruses traffic to the macaque CNS and cause astrocytosis early after inoculation.
      Singh, Dinesh K, et al.
      Virology, 296: 39-51 (2002)  2002

      Show Abstract
      12036316 12036316
      Expression of glial filament protein (GFP) in nerve sheaths and non-neural cells re-examined using monoclonal antibodies, with special emphasis on the co-expression of GFP and cytokeratins in epithelial cells of human salivary gland and pleomorphic adenomas.
      Achstätter, T, et al.
      Differentiation, 31: 206-27 (1986)  1986

      Show Abstract
      2429886 2429886
      Molecular interactions in intermediate-sized filaments revealed by chemical cross-linking. Heteropolymers of vimentin and glial filament protein in cultured human glioma cells.
      Quinlan, R A and Franke, W W
      Eur. J. Biochem., 132: 477-84 (1983)  1983

      Show Abstract
      6682757 6682757

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      Alternative Format

      Catalog Number Description  
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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies