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MAB3402B Anti-GFAP Antibody, Biotin Conjugate | MAB3402B

MAB3402B
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, H, R, Po, ChIHCMBiotinMonoclonal Antibody
      Description
      Catalogue NumberMAB3402B
      DescriptionAnti-GFAP Antibody, Biotin Conjugate | MAB3402B
      Alternate Names
      • Glial fibrillary acidic protein
      • GFAP
      Background InformationGlial fibrillary acidic protein is a class-III intermediate filament. GFAP is the main constituent of intermediate filaments in astrocytes and serves as a cell specific marker that distinguishes differentiated astrocytes from other glial cells during the development of the central nervous system.
      References
      Product Information
      FormatBiotin
      Control
      • Mouse adult brain tissue
      PresentationPurified mouse monoclonal IgG1 conjugated to Biotin in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Quality LevelMQ100
      Applications
      ApplicationAnti-GFAP Antibody, Biotin Conjugate detects level of GFAP & has been published & validated for use in IH.
      Key Applications
      • Immunohistochemistry
      Biological Information
      ImmunogenPurified glial filament protein (Debus, E., et al. (1983) Differentiation. 25:193-203.)
      HostMouse
      IsotypeIgG1
      Species Reactivity
      • Mouse
      • Human
      • Rat
      • Pig
      • Chicken
      Species Reactivity NoteDemonstrated to react with Mouse. Predicted to react with Human, Rat, Porcine, and Chicken based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].
      Gene Symbol
      • GFAP
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

      SIZE: 432 amino acids; 49880 Da

      SUBUNIT: Isoform 3 interacts with N-terminus of PSEN1.

      SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with intermediate filaments.

      DISEASE: Defects in GFAP are a cause of Alexander disease [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.

      SIMILARITY: Belongs to the intermediate filament family.
      Molecular Weight50 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in mouse adult brain tissue.

      Immunohistochemistry Analysis: 1:100 dilution of this antibody detected GFAP in mouse adult brain tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-GFAP Antibody, Biotin Conjugate | MAB3402B SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-GFAP Antibody, Biotin Conjugate | MAB3402B Certificates of Analysis

      TitleLot Number
      Anti-GFAP, Biotin Conjugate 2999789
      Anti-GFAP, Biotin Conjugate 3158075
      Anti-GFAP, Biotin Conjugate 2480935
      Anti-GFAP, Biotin Conjugate 2868355
      Anti-GFAP, Biotin Conjugate 2920705
      Anti-GFAP, Biotin Conjugate 3537156
      Anti-GFAP, Biotin Conjugate - 2197241 2197241
      Anti-GFAP, Biotin Conjugate - 2301295 2301295
      Anti-GFAP, Biotin Conjugate - 2829465 2829465
      Anti-GFAP, Biotin Conjugate - 2986137 2986137

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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies