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MABE415 Anti-FoxP2 Antibody, clone FOXP2-73A/8

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MABE415
100 µg  
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Overview

Replacement Information

Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHC, IPMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABE415
DescriptionAnti-FoxP2 Antibody, clone FOXP2-73A/8
Alternate Names
  • Forkhead box protein P2
  • CAG repeat protein 44
  • Trinucleotide repeat-containing gene 10 protein
Background InformationForkhead box protein P2 (FoxP2) is a multidomain transcriptional repressor that belongs to the Fox family of proteins. The FoxP2 protein contains a forkhead-box DNA-binding domain, characteristic of the FOX group of transcription factors. In addition, this protein contains a polyglutamine tract, as well as zinc finger and leucine zipper motifs. In order for FoxP2 to bind DNA, it forms homodimers and heterodimers with FoxP1 and FoxP4. The forkhead box family of proteins play an important role in immune response, organ development and the development of cancer. Functional studies in vertebrates suggest this gene plays a role in the modulation of neural plasticity. In line with these findings, mutations of FoxP2 in humans have been linked to speech and language disorders.
References
Product Information
FormatPurified
HS Code3002 15 90
PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect FOXP2 using this mouse monoclonal antibody, Anti-FoxP2 Antibody, clone FOXP2-73A/8 validated for use in western blotting & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
  • Immunoprecipitation
Application NotesWestern Blotting Analysis: 1 µg/mL from a representative lot detected FoxP2 in 10 µg of THP-1 cell lysate.

Immunoprecipitation Analysis (IP): A representative lot of this antibody was demonstrated to immunoprecipitate FoxP2 using growth arrested 143B cells (Gascoyne D.M., et al. (2015). PLoS One, 10(6):e0128513).

Immunohistochemistry Analysis: A representative lot from an independent laboratory detected FoxP2 in human tonsil tissues (Campbell, A. J., et al. (2010). Br J Haematol. 149(2):221-230.).

Immunohistochemistry Analysis: A representative lot from an independent laboratory detected FoxP2 in proliferating chondrocytes of murine E17.5 long bone (Gascoyne D.M., et al. (2015). PLoS One, 10(6):e0128513).
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to the N-terminus of Human FoxP2.
CloneFOXP2-73A/8
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityThis antibody recognizes FoxP2 isoforms at 70 kDa, 48 kDa, and 40 kDa.
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • FOXP2
  • CAGH44
  • TNRC10
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~80 kDa observed. Uniprot describes 9 isoforms between 9-83 kDa.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected FoxP2 in 10 µg of HeLa cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
MABE415 04053252923708

Documentation

Anti-FoxP2 Antibody, clone FOXP2-73A/8 SDS

Title

Safety Data Sheet (SDS) 

Anti-FoxP2 Antibody, clone FOXP2-73A/8 Certificates of Analysis

TitleLot Number
Anti-FoxP2, clone FOXP2-73A/8 - 3278590 3278590
Anti-FoxP2, clone FOXP2-73A/8 - 3560040 3560040
Anti-FoxP2, clone FOXP2-73A/8 - 3776224 3776224
Anti-FoxP2, clone FOXP2-73A/8 - 4191172 4191172
Anti-FoxP2, clone FOXP2-73A/8 - Q2273099 Q2273099
Anti-FoxP2, clone FOXP2-73A/8 -2736377 2736377
Anti-FoxP2, clone FOXP2-73A/8 -2786323 2786323
Anti-FoxP2, clone FOXP2-73A/8 -2789404 2789404
Anti-FoxP2, clone FOXP2-73A/8 Monoclonal Antibody 3023609
Anti-FoxP2, clone FOXP2-73A/8 Monoclonal Antibody 3146282

References

Reference overviewPub Med ID
The Forkhead Transcription Factor FOXP2 Is Required for Regulation of p21WAF1/CIP1 in 143B Osteosarcoma Cell Growth Arrest.
Gascoyne, DM; Spearman, H; Lyne, L; Puliyadi, R; Perez-Alcantara, M; Coulton, L; Fisher, SE; Croucher, PI; Banham, AH
PloS one  10  e0128513  2015

Show Abstract
26034982 26034982
Aberrant expression of the neuronal transcription factor FOXP2 in neoplastic plasma cells.
Campbell, Andrew J, et al.
Br. J. Haematol., 149: 221-30 (2010)  2010

Show Abstract
20096010 20096010