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07-2274 Anti-FSP1/S100A4 Antibody

07-2274
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, HWB, IH(P)RbPurifiedPolyclonal Antibody
      Description
      Catalogue Number07-2274
      DescriptionAnti-FSP1/S100A4 Antibody
      Alternate Names
      • S100 calcium binding protein A4
      • S100 calcium-binding protein A4
      • fibroblast-specific protein-1
      • leukemia multidrug resistance associated protein
      • S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog)
      • malignant transformation suppression 1
      • S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog)
      • Metastasin
      • Protein Mts1
      • Placental calcium-binding protein
      • Calvasculin
      Background InformationFibroblast-specific protein-1 (FSP1)/S100A4 is a cytoplasmic calcium-binding protein belonging to the S100 superfamily of which at least 21 members have been identified so far. Researchers believe that FSP1/S1004A is highly expressed in fibroblasts (Iwano et al., 2001; Strutz et al., 1995), in epithelial and endothelial cells undergoing epithelial-mesenchymal transition (EMT) (Iwano et al., 2002; Zeisberg and Neilson, 2009), and epithelial cancer cells that complete a transition to a metastatic phenotype (Xue et al., 2003).
      References
      Product Information
      FormatPurified
      Control
      • NIH/3T3 cell lysate
      PresentationPurified rabbit polyclonal containing PBS with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect the FSP1/S100A4 protein using this Anti-FSP1/S100A4 validated for use in WB & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesWestern Blot Analysis: 1 µg/mL from a previous lot detected S100-A4 on 10 µg of HeLa cell lysate.
      Biological Information
      ImmunogenHistidine-tagged recombinant protein corresponding to mouse FSP1/S100-A4.
      EpitopeUnknown
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Mouse
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • S100A4
      • CAPL
      • FSP1
      • 18A2
      • PEL98
      • P9KA
      • 42A
      • MTS1
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummarySUBUNIT STRUCTURE: Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode (by similarity).

      TISSUE SPECIFICTY: Specifically expressed in different metastatic cells.

      INDUCTION: The mRNA coding for this protein increases in abundance after serum stimulation of quiescent mouse fibroblasts.

      SEQUENCE SIMILARITIES: Belongs to the S-100 family.

      Contains 2 EF-hand domains.
      Molecular Weight~ 12 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in NIH/3T3 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected FSP1/S100-A4 on 10 µg of NIH/3T3 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-FSP1/S100A4 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-FSP1/S100A4 Antibody Certificates of Analysis

      TitleLot Number
      Anti-FSP1/S100A4 3071579
      Anti-FSP1/S100A4 - 2120074 2120074
      Anti-FSP1/S100A4 - 2145109 2145109
      Anti-FSP1/S100A4 - 2433484 2433484
      Anti-FSP1/S100A4 - 2453239 2453239
      Anti-FSP1/S100A4 - 1995599 1995599
      Anti-FSP1/S100A4 - 2006939 2006939
      Anti-FSP1/S100A4 - 2036120 2036120
      Anti-FSP1/S100A4 - 2281694 2281694
      Anti-FSP1/S100A4 - 2488825 2488825