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ABN467 Anti-CX3CL1 Antibody

ABN467
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN467
      DescriptionAnti-CX3CL1 Antibody
      Alternate Names
      • Fractalkine
      • C-X3-C motif chemokine 1
      • CX3C membrane-anchored chemokine
      • Neurotactin
      • Small-inducible cytokine D1
      • FKN
      • NTT
      • SCYD1
      • A-152E5.2
      Background InformationC-X3-C motif chemokine 1 (CX3CL1), also known as CX3C membrane-anchored chemokine, Neurotactin (NTT), Small-inducible cytokine D1 (SCYD1), and Fractalkine (FKN), is a CX3C chemokine known to induce adhesion and migration of leukocytes. Recent studies have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-alpha in activated microglia and neuronal cells, and it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Other evidence suggests that CX3CL1 may play a role in regulating leukocyte adhesion and migration processes at the endothelium. Additionally, CX3CL1 is implied to inhibit CX3CR1, which is a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection. CX3CL1 is expressed in small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas.
      References
      Product Information
      FormatAffinity Purified
      Control
      • C2C12 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-CX3CL1 Antibody is a highly specific rabbit polyclonal antibody, that targets CX3CL1 & has been tested in western blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human CX3CL1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Mouse
      Species Reactivity NoteDemonstrated to react with Mouse. Predicted to react with Human based on immunogen design.
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • CX3CL1
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~50 kDa observed.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in C2C12 cell lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected CX3CL1 in 15 µg of C2C12 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications