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AB3442 Anti-CREB Antibody, pSer133

AB3442
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, Mk, RWBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB3442
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CREB Antibody, pSer133
      Alternate Names
      • CREB-1
      • cAMP-response Element-binding Protein-1
      References
      Product Information
      FormatSerum
      PresentationRabbit serum. Liquid. The antibody has been preabsorbed with unphosphorylated peptide. Contains 0.01% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-CREB Antibody, pSer133 is a Rabbit Polyclonal Antibody for detection of CREB also known as CREB-1, cAMP-response Element-binding Protein-1 & has been validated in WB.
      Key Applications
      • Western Blotting
      Application NotesImmunoblotting: 1:500-1:1,000

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenPhosphopeptide conjugated to KLH.
      EpitopepSer133
      HostRabbit
      SpecificityRecognizes phosphorylated Serine133 in cAMP response element binding protein (CREB). By immunoblotting the antibody shows a 5-10 fold increase in staining of a 43 kDa protein after treatment of cells with agents that increase intracellular cAMP. The antibody also recognizes phosphorylated ATF-1 due to a common epitope. The antibody has been preabsorbed with unphosphorylated peptide and will prove to be useful for the investigation of CREB phosphorylation.
      Species Reactivity
      • Human
      • Mouse
      • Monkey
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
      Gene Symbol
      • CREB1
      • MGC9284
      • CREB
      Modifications
      • Phosphorylation
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P16220 # This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE.
      SIZE: 341 amino acids; 36688 Da
      SUBUNIT: Binds DNA as a dimer. Interacts PPRC1 and with HTLV-1 Tax-1.
      SUBCELLULAR LOCATION: Nucleus.
      PTM: Stimulated by phosphorylation. Phosphorylation of both Ser- 133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP and EP300 binding (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
      SIMILARITY: SwissProt: P16220 ## Belongs to the bZIP family. & Contains 1 bZIP domain. & Contains 1 KID (kinase-inducible) domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze-thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-CREB Antibody, pSer133 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-CREB Antibody, pSer133 Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-PHOSPHO-CREB 2470364
      RABBIT ANTI-PHOSPHO-CREB POLYCLONAL ANTIBODY - 2145021 2145021
      RABBIT ANTI-PHOSPHO-CREB POLYCLONAL ANTIBODY - 2326258 2326258
      RABBIT ANTI-PHOSPHO-CREB -2639444 2639444
      RABBIT ANTI-PHOSPHO-CREB -2728426 2728426
      RABBIT ANTI-PHOSPHO-CREB POLYCLONAL ANTIBODY 3111590

      References

      Reference overviewPub Med ID
      De novo protein synthesis of syntaxin-1 and dynamin-1 in long-term memory formation requires CREB1 gene transcription in Lymnaea stagnalis.
      Cong-Hui Guo,Anthony Senzel,Kathy Li,Zhong-Ping Feng
      Behavior genetics  40  2010

      Show Abstract
      20563839 20563839

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies