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AB1889 Anti-C-C Chemokine Receptor 5 Antibody, NT

AB1889
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB1889
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-C-C Chemokine Receptor 5 Antibody, NT
      Alternate Names
      • CCR-5
      • CD195
      Background InformationHIV and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G-protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors (1,2). Among them, CCR5 is a principle coreceptor for macrophage- and dual-tropic HIV-1 strains fusion of entry of human white blood cells (3,4). The amino-terminal domain and the extracellular loops of CCR5 serve as HIV binding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.
      References
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin. 100 μg purified IgG in 100 μL of PBS containing 0.2% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-C-C Chemokine Receptor 5 Antibody, N-terminus is an antibody against C-C Chemokine Receptor 5 for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:1000 - 1:2000 (THP-1 whole cell lysate can be used as a positive control)

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide from the N-terminal domain of human CCR5.
      EpitopeN-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificitySpecific for human C-C Chemokine Receptor 5 (CCR5) at the N-terminus.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.
      Gene Symbol
      • CCR5
      • CCCKR5
      • CMKBR5
      • chemr13
      • CD195
      • CKR5
      • CHEMR13
      • CC-CKR-5
      • CKR-5
      • CCR-5
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P51681 # Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ions level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.
      SIZE: 352 amino acids; 40524 Da
      SUBUNIT: Interacts with PRAF2. Interacts with HIV-1 surface protein gp120.
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Found in promyelocytic cells.
      PTM: Sulfation contributes to the efficiency of HIV-1 entry. & O-glycosylated, but not N-glycosylated.
      SIMILARITY: SwissProt: P51681 ## Belongs to the G-protein coupled receptor 1 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at 2-8°C for up to 12 months.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-C-C Chemokine Receptor 5 Antibody, NT SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-C-C Chemokine Receptor 5 Antibody, NT Certificates of Analysis

      TitleLot Number
      RABBIT ANTI- C-C CHEMOKINE RECEPTOR 5 (CCR5) N-TERMINUS 3171404
      RABBIT ANTI- C-C CHEMOKINE RECEPTOR 5 (CCR5) N-TERMINUS - 3306918 3306918
      RABBIT ANTI- C-C CHEMOKINE RECEPTOR 5 (CCR5) N-TERMINUS -2784664 2784664
      RABBIT ANTI- C-C CHEMOKINE RECEPTOR 5 (CCR5) N-TERMINUS -2792419 2792419
      RABBIT ANTI- C-C CHEMOKINE RECEPTOR 5 (CCR5) N-TERMINUS -2796250 2796250
      RABBIT ANTI- C-C CHEMOKINE RECEPTOR 5 (CCR5) N-TERMINUS -2816560 2816560
      RABBIT ANTI- C-C CHEMOKINE RECEPTOR 5 (CCR5) N-TERMINUS POLYCLONAL ANTIBODY -
      RABBIT ANTI- C-C CHEMOKINE RECEPTOR 5 (CCR5) N-TERMINUS POLYCLONAL ANTIBODY - 2383981 2383981
      RABBIT ANTI- C-C CHEMOKINE RECEPTOR 5 (CCR5) N-TERMINUS POLYCLONAL ANTIBODY -2594457 2594457
      RABBIT ANTI- C-C CHEMOKINE RECEPTOR 5 (CCR5) N-TERMINUS POLYCLONAL ANTIBODY -2608872 2608872

      References

      Reference overviewPub Med ID
      Chemokine receptors: keys to AIDS pathogenesis?
      Littman, D R
      Cell, 93: 677-80 (1998)  1998

      9630212 9630212
      How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity.
      Dimitrov, D S
      Cell, 91: 721-30 (1997)  1997

      9413981 9413981
      Identification of a major co-receptor for primary isolates of HIV-1.
      Deng, H, et al.
      Nature, 381: 661-6 (1996)  1996

      Show Abstract
      8649511 8649511
      HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.
      Dragic, T, et al.
      Nature, 381: 667-73 (1996)  1996

      Show Abstract
      8649512 8649512

      Data Sheet

      Title
      RABBIT ANTI- C-C CHEMOKINE RECEPTOR 5 (CCR5) N-TERMINUS