Key Specifications Table
|Species Reactivity||Key Applications||Host||Format||Antibody Type|
|Presentation||Purified immunoglobulin. 100 μg purified IgG in 100 μL of PBS containing 0.2% sodium azide.|
|Safety Information according to GHS|
|Storage and Shipping Information|
|Storage Conditions||Store at 2-8°C for up to 12 months.|
|Material Size||100 µg|
Anti-C-C Chemokine Receptor 5 Antibody, NT SDS
|Reference overview||Pub Med ID|
|Chemokine receptors: keys to AIDS pathogenesis?|
Littman, D R
Cell, 93: 677-80 (1998) 1998
|How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity.|
Dimitrov, D S
Cell, 91: 721-30 (1997) 1997
|Identification of a major co-receptor for primary isolates of HIV-1.|
Deng, H, et al.
Nature, 381: 661-6 (1996) 1996
Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1alpha and MIP-1beta.
|HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.|
Dragic, T, et al.
Nature, 381: 667-73 (1996) 1996
The beta-chemokines MIP-1alpha, MIP-1beta and RANTES inhibit infection of CD4+ T cells by primary, non-syncytium-inducing (NSI) HIV-1 strains at the virus entry stage, and also block env-mediated cell-cell membrane fusion. CD4+ T cells from some HIV-1-exposed uninfected individuals cannot fuse with NSI HIV-1 strains and secrete high levels of beta-chemokines. Expression of the beta-chemokine receptor CC-CKR-5 in CD4+, non-permissive human and non-human cells renders them susceptible to infection by NSI strains, and allows env-mediated membrane fusion. CC-CKR-5 is a second receptor for NSI primary viruses.
|RABBIT ANTI- C-C CHEMOKINE RECEPTOR 5 (CCR5) N-TERMINUS|