AB9042 Anti-Brain Derived Neurotrophic Factor Antibody, pro

AB9042
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R IP, WB, IHC Ch Semi-Purified Polyclonal Antibody
      Description
      Catalogue NumberAB9042
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Brain Derived Neurotrophic Factor Antibody, pro
      Alternate Names
      • proBDNF
      • pro BDNF
      References
      Product Information
      FormatSemi-Purified
      PresentationChicken immunoglobulin. Liquid.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Brain Derived Neurotrophic Factor Antibody, pro detects level of Brain Derived Neurotrophic Factor & has been published & validated for use in IP, WB, IH.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern blot: 1:500-1:1,000. Reacts with bands of 30 kD and 28 kD.Immunohistochemistry: 1:100-1:250 on frozen sections.

      Immunohistochemistry: 1:100-1:200

      Immunoprecipitation: 1:100

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenFusion protein from mouse proBDNF containing only the prodomain region.
      HostChicken
      SpecificityReacts with proBDNF. Does not recognize mature BDNF isoforms.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene, but the full-length nature of only some could be determined.
      Gene Symbol
      • BDNF
      • Abrineurin
      • neurotrophin
      • MGC34632
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P23560 # Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
      SIZE: 247 amino acids; 27818 Da
      SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB.
      SUBCELLULAR LOCATION: Secreted.
      PTM: The propeptide is N-glycosylated and glycosulfated. & Converted into mature BDNF by plasmin (PLG) (By similarity).
      DISEASE: SwissProt: P23560 # Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases.
      SIMILARITY: SwissProt: P23560 ## Belongs to the NGF-beta family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Brain Derived Neurotrophic Factor Antibody, pro SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Brain Derived Neurotrophic Factor Antibody, pro Certificates of Analysis

      TitleLot Number
      CHICKEN ANTI-proBDNF POLYCLONAL ANTIBODY - 24531642453164
      CHICKEN ANTI-proBDNF - 25584122558412
      CHICKEN ANTI-proBDNF - 32042343204234
      CHICKEN ANTI-proBDNF - 33194783319478
      CHICKEN ANTI-proBDNF -27762562776256
      CHICKEN ANTI-proBDNF POLYCLONAL ANTIBODY3117834
      CHICKEN ANTI-proBDNF POLYCLONAL ANTIBODY3004203
      CHICKEN ANTI-proBDNF POLYCLONAL ANTIBODY2945423
      CHICKEN ANTI-proBDNF POLYCLONAL ANTIBODY - 20427202042720
      CHICKEN ANTI-proBDNF POLYCLONAL ANTIBODY - 23245142324514

      References

      Reference overviewPub Med ID
      TrkB signaling directs the incorporation of newly generated periglomerular cells in the adult olfactory bulb.
      Bergami, M; Vignoli, B; Motori, E; Pifferi, S; Zuccaro, E; Menini, A; Canossa, M
      The Journal of neuroscience : the official journal of the Society for Neuroscience  33  11464-78  2013

      Show Abstract
      23843518 23843518
      Motoneuron programmed cell death in response to proBDNF.
      Taylor, AR; Gifondorwa, DJ; Robinson, MB; Strupe, JL; Prevette, D; Johnson, JE; Hempstead, B; Oppenheim, RW; Milligan, CE
      Developmental neurobiology  72  699-712  2012

      Show Abstract
      21834083 21834083
      Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice.
      Papaleo, F; Silverman, JL; Aney, J; Tian, Q; Barkan, CL; Chadman, KK; Crawley, JN
      Learning & memory (Cold Spring Harbor, N.Y.)  18  534-44  2011

      Show Abstract
      21791566 21791566
      Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons.
      Chen, Zhe-Yu, et al.
      J. Neurosci., 24: 4401-11 (2004)  2004

      Show Abstract
      15128854 15128854
      ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury.
      Beattie, Michael S, et al.
      Neuron, 36: 375-86 (2002)  2002

      Show Abstract
      12408842 12408842

      Data Sheet

      Title
      CHICKEN ANTI-proBDNF

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies