AB5613 Anti-Brain Derived Neurotrophic Factor Antibody, pro

AB5613
50 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R IHC, WB Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB5613
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Brain Derived Neurotrophic Factor Antibody, pro
      Alternate Names
      • Prepro-Abrineurin
      • Pro-Abrineurin
      • Prepro-BDNF
      • Pro-BDNF
      • Prepro-Brain-derived neurotrophic factor
      • Pro-Brain-derived neurotrophic factor
      Background InformationBrain-derived neurotrophic factor (UniProt P23560; also known as Abrineurin, BDNF, Neurotrophin) is encoded by the BDNF (also known as BULN2) gene (Gene ID 627) in human. BDNF is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous system. The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT3, and NT4/5. BDNF mediates its neurotrophic properties by signaling through the high affinity cell surface receptor gp145/trkB. BDNF is initially produced with a signal peptide (a.a. 1-18) and a propeptide (a.a. 19-128) sequence, the removal of which yields the mature BDNF (a.a. 129-247).
      References
      Product Information
      FormatSerum
      PresentationRabbit serum. Lyophilized. Reconstitute with 50 μL of sterile distilled water.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Brain Derived Neurotrophic Factor Antibody, pro is an antibody proBDNF for use in Immunohistochemistry and Western Blotting.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blot: 1:1,000-1:5,000

      Immunohistochemistry: 1:1,000-1:5,000

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to a region within human BDNF propeptide sequence.
      EpitopePropeptide.
      HostRabbit
      SpecificityThis polyclonal antiserum detects prepro- and pro-BDNF, as well as prepro-/pro-BDNF-derived N-terminal fragments that contain the propeptide sequence (a.a. 19-128), but not mature BDNF or C-terminal fragments without the propeptide sequence. No cross-reactivity to other proneurotrophins.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • BDNF
      UniProt Number
      Molecular Weight~35 kDa (glycosylated prepro-/pro-BDNF), ~50-65 kDa (glycosylated prepro-/pro-BDNF dimer), and ~26-28 kDa (non-glycosylated prepro/pro-BDNF or glycosylated prepro-/pro-BDNF N-terminal fragments) observed. Target bands appear larger than the calculated molecular weights of 27.82/28.87/29.82/37.12/31.12 kDa (human prepro-BDNF isoform 1/2/3/4/5) and 25.77/26.82/27.77/35.07/29.06 kDa (human pro-BDNF isoform 1/2/3/4/5) due to glycosylation and/or dimerization. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C for up to 6 months after date of receipt. After reconstitution maintain at -20°C undiluted for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (ACS grade or better) can be added (1:1) for additional stability.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Brain Derived Neurotrophic Factor Antibody, pro SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Brain Derived Neurotrophic Factor Antibody, pro Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-proBDNF - 25399732539973
      RABBIT ANTI-proBDNF - 31946383194638
      RABBIT ANTI-proBDNF -25101302510130
      RABBIT ANTI-proBDNF -25780932578093
      RABBIT ANTI-proBDNF -26156982615698
      RABBIT ANTI-proBDNF -26613002661300
      RABBIT ANTI-proBDNF -27015772701577
      RABBIT ANTI-proBDNF -27072052707205
      RABBIT ANTI-proBDNF POLYCLONAL ANTIBODY - 20747482074748
      RABBIT ANTI-proBDNF POLYCLONAL ANTIBODY - 25062772506277

      References

      Reference overviewPub Med ID
      Progesterone treatment alters neurotrophin/proneurotrophin balance and receptor expression in rats with traumatic brain injury.
      Milos Cekic,Sarah J Johnson,Vinay H Bhatt,Donald G Stein
      Restorative neurology and neuroscience  30  2012

      Show Abstract
      22232032 22232032

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      Alternative Format

      Catalog Number Description  
      AB5613P Anti-Brain Derived Neurotrophic Factor Antibody, pro Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies