AB9612 Anti-Brain Derived Neurotrophic Factor Antibody

AB9612
50 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R WB Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB9612
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Brain Derived Neurotrophic Factor Antibody
      References
      Product Information
      FormatSerum
      PresentationRabbit serum. Lyophilized. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any insoluble material.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Brain Derived Neurotrophic Factor Antibody is validated for use in WB for the detection of Brain Derived Neurotrophic Factor.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:500-1:2,000

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide from mouse BDNF.
      HostRabbit
      SpecificityBrain Derived Neurotrophic Factor (BDNF). By Western blot the antibody reacts with recombinant BDNF protein and also detects the ~28 kDa proBDNF protein in rat brain extracts. The antibody shows no cross reactivity with NGF, NT3 or NT4/5 by Western blot.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene, but the full-length nature of only some could be determined.
      Gene Symbol
      • BDNF
      • Abrineurin
      • neurotrophin
      • MGC34632
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P23560 # Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
      SIZE: 247 amino acids; 27818 Da
      SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB.
      SUBCELLULAR LOCATION: Secreted.
      PTM: The propeptide is N-glycosylated and glycosulfated. & Converted into mature BDNF by plasmin (PLG) (By similarity).
      DISEASE: SwissProt: P23560 # Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases.
      SIMILARITY: SwissProt: P23560 ## Belongs to the NGF-beta family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20 to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Brain Derived Neurotrophic Factor Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Brain Derived Neurotrophic Factor Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI- BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF)2488725
      RABBIT ANTI- BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF)2484046
      RABBIT ANTI- BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) (For Western Blot Use) POLYCLONAL ANTIBODY - 20300192030019
      RABBIT ANTI- BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) (For Western Blot Use) POLYCLONAL ANTIBODY - 20740502074050
      RABBIT ANTI- BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) (For Western Blot Use) POLYCLONAL ANTIBODY - 22763692276369
      RABBIT ANTI- BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) (For Western Blot Use) POLYCLONAL ANTIBODY - 22765902276590
      RABBIT ANTI- BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) (For Western Blot Use) POLYCLONAL ANTIBODY - 23200212320021
      RABBIT ANTI- BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) - 34402623440262
      RABBIT ANTI- BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) -25793932579393
      RABBIT ANTI- BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) -26613172661317

      References

      Reference overviewApplicationPub Med ID
      A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice.
      Chatterjee, S; Mizar, P; Cassel, R; Neidl, R; Selvi, BR; Mohankrishna, DV; Vedamurthy, BM; Schneider, A; Bousiges, O; Mathis, C; Cassel, JC; Eswaramoorthy, M; Kundu, TK; Boutillier, AL
      The Journal of neuroscience : the official journal of the Society for Neuroscience  33  10698-712  2013

      Show Abstract
      Western Blotting23804093 23804093

      Data Sheet

      Title
      RABBIT ANTI- BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) (For Western Blot Use) POLYCLONAL ANTIBODY

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies