AB15708A4 Anti-Beta III Tubulin Antibody, Alexa Fluor® 488 Conjugate | AB15708A4

AB15708A4
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, M, H ICC, IHC Rb AlexaFluor®488 Polyclonal Antibody
      Description
      Catalogue NumberAB15708A4
      DescriptionAnti-Beta III Tubulin Antibody, Alexa Fluor® 488 Conjugate | AB15708A4
      Alternate Names
      • Tubulin beta-4
      • Tubulin beta-III
      • tubulin, beta 3
      • tubulin, beta, 4
      Background InformationTubulin is one of several members of a small family of globular proteins which polymerize to form cytoskeletal structures called microtubules. The most common members of the tubulin family are α-tubulin and β-tubulin. Tubulin dimers, typically composed of α- and β-tubulin subunits, assemble onto microtubules forming large polymers. β-III tubulin is a unique microtubule subunit that is found expressed almost exclusively in neurons. Due to the unique expression pattern of β-III tubulin it is often utilized as a marker to identify neuronal cells from other brain cells such as glia which do not express it. β-III tubulin also serves as a cytoarchitectural marker since it is primarily found within neurite extensions.
      References
      Product Information
      FormatAlexaFluor®488
      Control
      • Rat E18 cortex cells
      PresentationPurified rabbit polyclonal conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Quality LevelMQ100
      Applications
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      Application NotesImmunohistochemistry: Representive lot has been shown to work in adult mouse brain.
      Biological Information
      ImmunogenSynthetic linear peptide corresponding to human Beta III Tubulin.
      HostRabbit
      SpecificityThis antibody recognizes Beta III Tubulin.
      Species Reactivity
      • Rat
      • Mouse
      • Human
      Species Reactivity NoteDemonstrated to react with Rat and Mouse. Predicted to react with Human based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6.
      Gene Symbol
      • TUBB3
      • TUBB4
      • MC1R
      • beta-4
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.

      SIZE: 450 amino acids; 50433 Da

      SUBUNIT: Dimer of alpha and beta chains.

      DOMAIN: The highly acidic C-terminal region may bind cations such as calcium.

      SIMILARITY: Belongs to the tubulin family.
      Molecular Weight50 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemistry in rat E18 cortex cells.

      Immunocytochemistry Analysis: A 1:400 dilution of this antibody detected Beta III Tubulin in rat E18 cortex cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Beta III Tubulin Antibody, Alexa Fluor® 488 Conjugate | AB15708A4 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Beta III Tubulin Antibody, Alexa Fluor® 488 Conjugate | AB15708A4 Certificates of Analysis

      TitleLot Number
      Anti-Beta III Tubulin, Alexa Fluor#174; 488 Conjugate - 20313582031358
      Anti-Beta III Tubulin, Alexa Fluor#174; 488 Conjugate - 21072822107282
      Anti-Beta III Tubulin, Alexa Fluor#174; 488 Conjugate - 22244522224452
      Anti-Beta III Tubulin, Alexa Fluor® 488 -25681492568149
      Anti-Beta III Tubulin, Alexa Fluor® 488 -28061232806123
      Anti-Beta III Tubulin, Alexa Fluor® 488 Conjugate2890907
      Anti-Beta III Tubulin, Alexa Fluor® 488 Conjugate2967905
      Anti-Beta III Tubulin, Alexa Fluor® 488 Conjugate3030312
      Anti-Beta III Tubulin, Alexa Fluor® 488 Conjugate2884285
      Anti-Beta III Tubulin, Alexa Fluor® 488 Conjugate - 24248232424823

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies