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AB2204 Anti-BMAL1 Antibody

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50 µL  
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Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWBGpSerumPolyclonal Antibody
Catalogue NumberAB2204
DescriptionAnti-BMAL1 Antibody
Alternate Names
  • ARNT-like protein 1, brain and muscle
  • Basic-helix-loop-helix-PAS protein MOP3
  • Brain and muscle ARNT-like 1, member of PAS protein 3
  • aryl hydrocarbon receptor nuclear translocator-like
  • bHLH-PAS protein JAP3
  • basic-helix-loop-helix-PAS orphan MOP3 2, member of PAS superfamily 3
Background InformationBrain and muscle Arnt-like protein-1 (BMAL1; also known as MOP3 or Arnt3) is a transcription factor known to regulate circadian rhythm. BMAL1 is the only component of the mammalian circadian clock whose sole deletion in a mouse model generates arrhythmicity. In addition to defects in the clock, these BMAL1 null-mice also have reproductive problems are small in stature, age quickly and have progressive arthropathy that results in having less overall locomotor activity than wild type mice. Recent phenotyping data suggests that BMAL1 and its partner Clock also play a role in regulation of glucose homeostasis and metabolism. Finally, BMAL1, NPAS2, and PER2 have been associated with seasonal affective disorder in humans. BMAL1 transcription is circadian and reciprocally regulated by NR1D1 (Rev-erb-alpha) and RORA, which establishes a second interlocking loop in the mammalian circadian clock.
Product Information
  • C2C12 Tissue lysate
PresentationSerum with 0.05% NaN3
Quality LevelMQ100
ApplicationAnti-BMAL1 Antibody is an antibody against BMAL1 for use in WB.
Key Applications
  • Western Blotting
Biological Information
ImmunogenRecombinant Protein
HostGuinea Pig
SpecificityCat. # AB2204 will recognize the C-terminus of BMAL1.
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity NoteMouse, Human and Rat. Reactivity with other species has not been tested.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • BMAL1
  • BMAL1c
  • JAP3
  • MGC47515
  • MOP3
  • PASD3
  • TIC
UniProt Number
UniProt SummaryFUNCTION: ARNTL-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity).
SUBUNIT: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-ARNTL heterodimer with PER or CRY inhibits transcription activation. Interacts with HSP90; with AHR in vitro, but not in vivo.
SUBCELLULAR LOCATION: Nucleus (By similarity).
ALTERNATIVE PRODUCTS: 8 named isoforms [FASTA] produced by alternative splicing. Additional isoforms seem to exist.
Molecular Weight~69 kDa.
Physicochemical Information
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely tested on C2C12 tissue lysate
Lot Specific Tested Application 1: Western Blot
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.
Packaging Information
Material Size50 µL
Transport Information
Supplemental Information
Global Trade Item Number
Catalog Number GTIN
AB2204 04053252270703


Anti-BMAL1 Antibody SDS


Safety Data Sheet (SDS) 

Anti-BMAL1 Antibody Certificates of Analysis

TitleLot Number
Anti-BMAL1 - 2455610 2455610
Anti-BMAL1 - 2060991 2060991
Anti-BMAL1 - 2246845 2246845
Anti-BMAL1 - 2298435 2298435
Anti-BMAL1 - 3290800 3290800
Anti-BMAL1 - 3437954 3437954
Anti-BMAL1 - 3448839 3448839
Anti-BMAL1 - 3722056 3722056
Anti-BMAL1 - 3805294 3805294
Anti-BMAL1 - 3958305 3958305


Reference overviewPub Med ID
Antibodies for assessing circadian clock proteins in the rodent suprachiasmatic nucleus.
LeSauter, J; Lambert, CM; Robotham, MR; Model, Z; Silver, R; Weaver, DR
PloS one  7  e35938  2012

Show Abstract
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Mop3 is an essential component of the master circadian pacemaker in mammals.
Bunger, M K, et al.
Cell, 103: 1009-17 (2000)  2000

Show Abstract
11163178 11163178
Rapid resetting of the mammalian circadian clock.
Best, J D, et al.
J. Neurosci., 19: 828-35 (1999)  1999

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