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AB2218 Anti-Aquaporin 4 Antibody

AB2218
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB2218
      ReplacesAB3068
      Trade Name
      • Chemicon
      DescriptionAnti-Aquaporin 4 Antibody
      Alternate Names
      • AQP4
      • WCH4
      • MIWC
      Background InformationThe water-specific channel Aquaporin 4 is located in various tissues including the gastro intestinal tract, kidney and brain. It is an osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. The localization of AQ4 to astrocyte endfeet makes it an excellent marker for astrocyte distal processes.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Tested on adult rat brain lysate
      PresentationPurified in PBS with 0.05% NaN3
      Quality LevelMQ100
      Applications
      ApplicationAnti-Aquaporin 4 Antibody is an antibody against Aquaporin 4 for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting: 0.5-1 μg/mL using Chemiluminescence technique.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic Linear Peptide
      EpitopeC-Terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes Aquaporin 4.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteThe antibody has not yet been tested for cross-reactivity to other species.


      The immunogen shows 94% similarity to mouse, 88% to bovine, 86% to rabbit and 82% to human AQP4 (hAQP4).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
      Gene Symbol
      • AQP4
      • MIWC
      • WCH4
      • AQP-4
      • aquaporin-4
      • HMIWC2
      • Aquaporin-4
      • MGC22454
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P55087 # Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
      SIZE: 323 amino acids; 34830 Da
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Brain - muscle > heart, kidney, lung, and trachea.
      DOMAIN: SwissProt: P55087 Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
      SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
      Molecular Weight~34 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Aquaporin 4 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Aquaporin 4 Antibody Certificates of Analysis

      TitleLot Number
      Anti-Aquaporin 4 - 2118038 2118038
      Anti-Aquaporin 4 - 2326380 2326380
      Anti-Aquaporin 4 - 2424775 2424775
      Anti-Aquaporin 4 - NG1853741 NG1853741
      Anti-Aquaporin 4 - 1970730 1970730
      Anti-Aquaporin 4 - 2026027 2026027
      Anti-Aquaporin 4 - 2038263 2038263
      Anti-Aquaporin 4 - 2203069 2203069
      Anti-Aquaporin 4 - 2302189 2302189
      Anti-Aquaporin 4 - 2894073 2894073

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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies