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MABN452 Anti-Adenosine Deaminase Antibody, clone 9H12.1

MABN452
200 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN452
      DescriptionAnti-Adenosine Deaminase Antibody, clone 9H12.1
      Alternate Names
      • Adenosine deaminase CECR1
      • Cat eye syndrome critical region protein 1
      • CECR1
      Background InformationAdenosine deaminase, also known as ADA, or Cat eye syndrome critical region protein 1, and encoded by the gene CECR1/ADA2/ADGF/IDGFL, is an extracellular enzyme that works on adenosine and causes the degradation of adenosine to inosine and free NH3. Adenosine deaminase is an extracellular secreted enzyme that binds to cell surfaces via proteoglycans. The binding appears to mediate cellular proliferation and differentiation in many systems, though this activity is independent of its deaminase activity. Adenosine deaminase is highly present in blood plasma and widely expressed in adult and fetal tissues. While there many clinical deficiencies associated with adenosine deaminase (ADA) mutations, the level of ADA activity in the blood and fluids is used as a biomarker to help distinguish various diseases. For instance, the level of activity in lung fluid is correlated with tuberculosis infection and used to distinguish it from malignant pleural effusion (MPE). The ADA level in CSF in patients with meningitis also helps to identify tuberculosis as the cause as opposed to another agent or condition.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Adenosine Deaminase Antibody, clone 9H12.1 is validated for use in western blotting & IHC (Paraffin) for the detection of Adenosine Deaminase.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Adenosine Deaminase in human placenta tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Adenosine Deaminase.
      Clone9H12.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgMκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CECR1
      • ADA2
      • ADGF
      • IDGFL
      Purification MethodPurified by Ion-Exchange Chromatography
      UniProt Number
      Molecular Weight~ 60 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human placenta tissue lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected Adenosine Deaminase in 10 µg of human placenta tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications