164605 Aminopeptidase N (CD13), Human Serum

164605
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164605-10UG
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      Plastic ampoule 10 μg
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      Description
      OverviewNative aminopeptidase N purified from human serum. Aminopeptidase N is a single-chain, integral membrane protease with broad specificity that functions to remove N-terminal amino acids from peptides. It also acts as a receptor for coronavirus and is known to play a role in angiogenesis, HIV entry, and in degradation of extracellular matrix as a result of tumor invasion.
      Catalogue Number164605
      Brand Family Calbiochem®
      SynonymsAPN/CD13, Aminopeptidase N
      References
      ReferencesBhagwat, S.V., et al. 2003. Blood 101, 1818.
      Kawai, M., et al. 2001. Clin. Chem. 47, 223.
      Watanabe, Y., et al. 1998. Mol. Genet. Metab. 63, 289.
      Pulido-Cejudo, G., et al. 1997. Antiviral Res. 36, 167.
      Hansen, A.S., et al. 1993. Eur. J. Immunol. 23, 2358.
      Saiki, I., et al. 1993. Int. J. Cancer 54,137.
      Shipp, M.A. and Look, A.T. 1993. Blood 82, 1052.
      Yeager, C.L., et al. 1992. Nature 357, 420.
      Product Information
      Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol L-leucine-p-nitroanilide) per min at 37°C, pH 7.2.
      EC number3.4.11.2
      FormLiquid
      FormulationIn 150 mM NaCl, 50 mM Tris-HCl, 1 mM CaCl₂, pH 8.0.
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥92% by SDS-PAGE
      SourcePrepared from human serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Specific Activity≥450 mU/mg protein
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Aminopeptidase N (CD13), Human Serum Certificates of Analysis

      TitleLot Number
      164605

      References

      Reference overview
      Bhagwat, S.V., et al. 2003. Blood 101, 1818.
      Kawai, M., et al. 2001. Clin. Chem. 47, 223.
      Watanabe, Y., et al. 1998. Mol. Genet. Metab. 63, 289.
      Pulido-Cejudo, G., et al. 1997. Antiviral Res. 36, 167.
      Hansen, A.S., et al. 1993. Eur. J. Immunol. 23, 2358.
      Saiki, I., et al. 1993. Int. J. Cancer 54,137.
      Shipp, M.A. and Look, A.T. 1993. Blood 82, 1052.
      Yeager, C.L., et al. 1992. Nature 357, 420.

      Brochure

      Title
      New Research Tools for Signal Transduction and Life Science Research
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-September-2007 RFH
      SynonymsAPN/CD13, Aminopeptidase N
      DescriptionNative aminopeptidase N purified from human serum. Aminopeptidase N is a single-chain, integral membrane protease with broad specificity that functions to remove N-terminal amino acids from peptides. It also acts as a receptor for coronavirus and is known to play a role in angiogenesis, HIV entry, and in degradation of extracellular matrix as a result of tumor invasion. Activity is inhibited by amastatin, actinonin, and bestatin (Cat. No. 200484) (~150 µM).
      FormLiquid
      FormulationIn 150 mM NaCl, 50 mM Tris-HCl, 1 mM CaCl₂, pH 8.0.
      SourcePrepared from human serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      EC number3.4.11.2
      Purity≥92% by SDS-PAGE
      Specific activity≥450 mU/mg protein
      Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol L-leucine-p-nitroanilide) per min at 37°C, pH 7.2.
      Storage ≤ -70°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesBhagwat, S.V., et al. 2003. Blood 101, 1818.
      Kawai, M., et al. 2001. Clin. Chem. 47, 223.
      Watanabe, Y., et al. 1998. Mol. Genet. Metab. 63, 289.
      Pulido-Cejudo, G., et al. 1997. Antiviral Res. 36, 167.
      Hansen, A.S., et al. 1993. Eur. J. Immunol. 23, 2358.
      Saiki, I., et al. 1993. Int. J. Cancer 54,137.
      Shipp, M.A. and Look, A.T. 1993. Blood 82, 1052.
      Yeager, C.L., et al. 1992. Nature 357, 420.