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119139 Adenosine A₃ Receptor Agonist, 2-Cl-IB-MECA - CAS 163042-96-4 - Calbiochem

A highly selective agonist of adenosine A3 receptor (Ki = 330 pM)

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Cl-IB-MECA, 2-chloro-IB-MECA

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119139
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
163042-96-4C₁₈H₁₈ClIN₆O₄

Products

Catalog NumberPackaging Qty/Pack
119139-2MG Glass bottle 2 mg
Description
OverviewAn adenosine analog that acts as a highly selective agonist of adenosine A3 receptor (Ki = 330 pM, 820 nM, 470 nM for A3, A1 and A2A, respectively). Shown to reduce ischemia reperfusion injury in mice and limit infarct size in isolated rat hearts. Shown to reversibly increase field excitatory postsynaptic potentials in hippocampal slices and exhibits excitatory effects on both evoked and spontaneous epileptiform discharges.
Catalogue Number119139
Brand Family Calbiochem®
Synonyms2-Cl-IB-MECA, 2-chloro-IB-MECA
References
ReferencesKim, H. O., et al. 1994. J Med Chem. 37, 3614.
Laudadio, M. A., et al. 2004. Epilepsy Res. 59, 83.
Ge, Z.D., et al. 2006. J. Pharm. Exp. Ther. 319, 1200.
Product Information
CAS number163042-96-4
FormWhite solid
Hill FormulaC₁₈H₁₈ClIN₆O₄
Chemical formulaC₁₈H₁₈ClIN₆O₄
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
119139-2MG 04055977223347

Documentation

Adenosine A₃ Receptor Agonist, 2-Cl-IB-MECA - CAS 163042-96-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Adenosine A₃ Receptor Agonist, 2-Cl-IB-MECA - CAS 163042-96-4 - Calbiochem Certificates of Analysis

TitleLot Number
119139

References

Reference overview
Kim, H. O., et al. 1994. J Med Chem. 37, 3614.
Laudadio, M. A., et al. 2004. Epilepsy Res. 59, 83.
Ge, Z.D., et al. 2006. J. Pharm. Exp. Ther. 319, 1200.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-April-2014 JSW
Synonyms2-Cl-IB-MECA, 2-chloro-IB-MECA
DescriptionAn adenosine analog that acts as a highly selective agonist of adenosine A3 receptor (Ki = 330 pM, 820 nM, 470 nM for A3, A1 and A2A, respectively). Shown to reduce ischemia reperfusion injury in mice and limit infarct size in isolated rat hearts. Shown to reversibly increase field excitatory postsynaptic potentials in hippocampal slices and exhibits excitatory effects on both evoked and spontaneous epileptiform discharges.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number163042-96-4
Chemical formulaC₁₈H₁₈ClIN₆O₄
Purity≥98% by HPLC
SolubilityDMSO (20 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKim, H. O., et al. 1994. J Med Chem. 37, 3614.
Laudadio, M. A., et al. 2004. Epilepsy Res. 59, 83.
Ge, Z.D., et al. 2006. J. Pharm. Exp. Ther. 319, 1200.