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533756 Ac-CoA Synthase Inhibitor - CAS 508186-14-9 - Calbiochem

533756
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Key Specifications Table

Empirical FormulaCAS #
C₂₀H₁₈N₄O₂S₂ 508186-14-9

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      Glass bottle 25 mg
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      Description
      OverviewA cell-permeable quinoxaline based compound that acts as a potent, reversible inhibitor of acetyl CoA synthetase (ACSS2; IC50 ~ 600 nM in a luciferase based assay). Exhibits selectivity over ACSF2 and ACSL5 acyl-CoA synthetases. Efficiently blocks the uptake of 14C tracer carbons from acetate into lipids (IC50 = 6.8 µM) and for histone acetylation (IC50 = 5.5 µM) in HepG2 cells.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number533756
      Brand Family Calbiochem®
      Synonyms1-(2,3-di(Thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea, N-(2,3-di-2-Thienyl-6-quinoxalinyl)-Nʹ-(2-methoxyethyl)urea, Acyl-CoA Synthetase 2 short-chain Inhibitor; short-chain Acetyl-CoA Synthetase 2 Inhibitor, ACSS2 Inhibitor
      References
      ReferencesComerford, S.A., et al. 2014. Cell. 159, 1591.
      Product Information
      CAS number508186-14-9
      FormYellow solid
      Hill FormulaC₂₀H₁₈N₄O₂S₂
      Chemical formulaC₂₀H₁₈N₄O₂S₂
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetACSS2
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ac-CoA Synthase Inhibitor - CAS 508186-14-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Comerford, S.A., et al. 2014. Cell. 159, 1591.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-July-2017 JSW
      Synonyms1-(2,3-di(Thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea, N-(2,3-di-2-Thienyl-6-quinoxalinyl)-Nʹ-(2-methoxyethyl)urea, Acyl-CoA Synthetase 2 short-chain Inhibitor; short-chain Acetyl-CoA Synthetase 2 Inhibitor, ACSS2 Inhibitor
      DescriptionA cell-permeable quinoxaline based compound that acts as a potent, reversible inhibitor of acetyl CoA synthetase (ACSS2; IC50 ~ 600 nM in a luciferase based assay). Exhibits selectivity over ACSF2 and ACSL5 acyl-CoA synthetases. Efficiently blocks the uptake of 14C tracer carbons from acetate into lipids (IC50 = 6.8 µM) and for histone acetylation (IC50 = 5.5 µM) in HepG2 cells.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number508186-14-9
      Chemical formulaC₂₀H₁₈N₄O₂S₂
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesComerford, S.A., et al. 2014. Cell. 159, 1591.