531621 APT2 Inhibitor, Cpd1 - Calbiochem

531621
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₃H₂₂N₂O₄S₂

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      Glass bottle 10 mg
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      Description
      OverviewA cell permeable acetylpiperazine derivative that acts as a selective and reversible inhibitor of lysophopholipase 2 (LYPLA2; IC50 = 510 nM, Ki = 230 nM) without affecting the activity of LYPLA1 and 25 other serine hydrolases in mouse BW5147 T cell hydridoma proteome. Shown to cause an almost complete inhibition (+90%) of LYPLA2 activity in lung, heart, and kidney (50 mg/kg, 3 h), and in HEK293T, and mouse T cells (~ 5 µM for 3 h).

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531621
      Brand Family Calbiochem®
      SynonymsLysophosphilipase 2 Inhibitor, LYPLA2 Inhibitor
      References
      ReferencesAdibekian, A., et al. 2012. J. Am. Chem. Soc. 134, 10345.
      Product Information
      FormPale orange powder
      Hill FormulaC₂₃H₂₂N₂O₄S₂
      Chemical formulaC₂₃H₂₂N₂O₄S₂
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAPT2
      Primary Target IC<sub>50</sub>510 nM, Ki
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      APT2 Inhibitor, Cpd1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Adibekian, A., et al. 2012. J. Am. Chem. Soc. 134, 10345.

      Technical Info

      Title
      Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
      White Paper: Further considerations of antibody validation and usage. (EMD)
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-March-2015 JSW
      SynonymsLysophosphilipase 2 Inhibitor, LYPLA2 Inhibitor
      DescriptionA cell permeable acetylpiperazine derivative that acts as a selective and reversible inhibitor of lysophopholipase 2 (LYPLA2; IC50 = 510 nM, Ki = 230 nM) without affecting the activity of LYPLA1 and 25 other serine hydrolases in mouse BW5147 T cell hydridoma proteome. Shown to cause an almost complete inhibition (+90%) of LYPLA2 activity in lung, heart, and kidney (50 mg/kg, 3 h), and in HEK293T, and mouse T cells (~ 5 µM for 3 h).
      FormPale orange powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₃H₂₂N₂O₄S₂
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesAdibekian, A., et al. 2012. J. Am. Chem. Soc. 134, 10345.