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531620 APT1 Inhibitor II, Cpd21 - Calbiochem

531620
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₈H₁₇ClF₃N₃O₃

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      Glass bottle 10 mg
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      Description
      OverviewA cell permeable acetylpiperazine derivative compound that acts as a selective and reversible inhibitor of lysophospholipase 1 (LYPLA1; IC50 = 840 nM, Ki = 300 nM) without affecting the activity of LYPLA2 and 25 other serine hydrolases in mouse BW5147 T cell hydridoma proteome. Shown to cause an almost complete inhibition (+90%) of LYPLA1 activity in lung, heart, and kidney (50 mg/kg, 3 h), and in HEK293T, and mouse T cells (~ 5 µM for 3 h).

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531620
      Brand Family Calbiochem®
      SynonymsLYPLA1 Inhibitor, Lysophospholipase Inhibitor
      References
      ReferencesAdibekian, A., et al. 2012. J. Am. Chem. Soc. 134, 10345.
      Product Information
      FormWhite solid
      Hill FormulaC₁₈H₁₇ClF₃N₃O₃
      Chemical formulaC₁₈H₁₇ClF₃N₃O₃
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAPT1
      Primary Target IC<sub>50</sub>840 nM, Ki
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      APT1 Inhibitor II, Cpd21 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Adibekian, A., et al. 2012. J. Am. Chem. Soc. 134, 10345.

      Brochure

      Title
      NPI Flyer- Epigenetics and Nuclear Function Feature (EMD)
      New Products - Antibodies, Small Molecule, Inhibitors

      Technical Info

      Title
      White Paper: Further considerations of antibody validation and usage. (EMD)
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-December-2014
      SynonymsLYPLA1 Inhibitor, Lysophospholipase Inhibitor
      DescriptionA cell permeable acetylpiperazine derivative compound that acts as a selective and reversible inhibitor of lysophospholipase 1 (LYPLA1; IC50 = 840 nM, Ki = 300 nM) without affecting the activity of LYPLA2 and 25 other serine hydrolases in mouse BW5147 T cell hydridoma proteome. Shown to cause an almost complete inhibition (+90%) of LYPLA1 activity in lung, heart, and kidney (50 mg/kg, 3 h), and in HEK293T, and mouse T cells (~ 5 µM for 3 h).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₈H₁₇ClF₃N₃O₃
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesAdibekian, A., et al. 2012. J. Am. Chem. Soc. 134, 10345.