GF165 ANG-2 Protein, Human Recombinant

GF165
20 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      SourcePurity
      CHO Cells Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 95% pure by SDS-PAGE gel and HPLC analyses
      Description
      Catalogue NumberGF165
      DescriptionANG-2 Protein, Human Recombinant
      Alternate Names
      • ANG2
      • ANG
      • Angiopoietin 2
      • ANGPT2
      Background InformationAngiopoietin2 (Ang-2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Ang-2 is widely expressed during development, but it is restricted postnatally to highly angiogenic tissues such as the placenta, ovaries, and uterus. It is particularly abundant in vascular endothelial cells (EC) where it is stored in intracellular Weibel Palade bodies. ANG-2 binds to the endothelial cell specific receptor Tie2, but, in contrast to ANG-1 does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie2 and, depending on the physiological and biochemical environment, can act either as a n agonist or antagonist of Tie2 induced angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels. Mature human ANG-2 is a secreted protein containing 480 amino acid residues. ANG-2 is composed of an α helix rich “coiled coil” N-terminal domain and fibrinogen like C-terminal domain. ANG-2 exists predominantly in the form of a disulfide-linked dimer. Recombinant human ANG-2 is a C-terminal histidine tagged glycoprotein which migrates with an apparent molecular mass of 60.0 – 70.0 kDa by SDS-PAGE under reducing conditions. Sequencing analysis shows an N-terminal sequence starting with residue 68 (D) of the ANG-2 precursor protein.
      References
      Product Information
      PresentationProduct is filtered through a 0.2 micron filter before lyophilization.
      Quality LevelMQ100
      Applications
      ApplicationAngiopoietin2 (Ang-2) is a secreted glycoprotein that plays a complex role in angiogenesis & inflammation.
      Biological Information
      PurityProduct is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 95% pure by SDS-PAGE gel and HPLC analyses
      SourceCHO Cells
      Cross ReactivityNone
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceBioactivity assay: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC). Bioactivity assay: Determined by its ability to stimulate tubulogenesis in HUVEC cells using a concentration of 0.2μg/ml.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C for up to 6 months from date of receipt.
      Packaging Information
      Material Size20 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      ANG-2 Protein, Human Recombinant SDS

      Title

      Safety Data Sheet (SDS) 

      ANG-2 Protein, Human Recombinant Certificates of Analysis

      TitleLot Number
      Recombinant Human -25415722541572
      Recombinant Human -26953012695301
      Recombinant Human ANG-2 -31671623167162
      Recombinant Human ANG-2 - 21351322135132
      Recombinant Human ANG-2 - 23000222300022
      Recombinant Human ANG-2 - 25154182515418
      Recombinant Human ANG-2 - Q2007171Q2007171
      Recombinant Human ANG-2 -25116522511652
      Recombinant Human ANG-2 Recombinant Protein3043075

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      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors