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171258 AMPK Signaling Activator XV - CAS 844499-71-4 - Calbiochem

A cell-permeable, direct, potent, selective, reversible, and allosteric activator of AMPK (EC₅₀ = 0.8 µM for rat liver).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6,7-Dihydro-4-hydroxy-3-(2ʹ-hydroxy(1,1ʹ-biphenyl)-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile, A769662, 4-Hydroxy-3-(2ʹ-hydroxybiphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile

171258
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
844499-71-4C₂₀H₁₂N₂O₃S

Products

Catalog NumberPackaging Qty/Pack
171258-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable thienopyridone compound that acts as a direct, potent, selective, reversible, and allosteric activator of AMPK (EC50 = 0.8 µM, 1.9 µM and 2.2 µM in partially purified AMPK from rat liver, muscle and heart, respectively; 0.7 µM for AMPKα1,β1,γ1 isoform and 1.1 µM in HEK cells). Acts by inhibiting the dephosphorylation of AMPKT172. Does neither affect GPPase and FBPase activities at 100 µM, and a panel of 67-receptors and ion-channels at 10 µM nor alter the intracellular levels of ATP and AMP. Specifically stimulates hepatic AMPK in ob/ob mouse model (30 mg/kg, i.p.), improves insulin-sensitivity and regulates glucose and lipid metabolism. Shown to reduce mRNA expression levels of several gluconeogenic enzymes.
Catalogue Number171258
Brand Family Calbiochem®
Synonyms6,7-Dihydro-4-hydroxy-3-(2ʹ-hydroxy(1,1ʹ-biphenyl)-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile, A769662, 4-Hydroxy-3-(2ʹ-hydroxybiphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
References
ReferencesSanders, M.J., et al. 2007. J. Biol. Chem. 282, 32539.
Cool, B., et al. 2006. Cell Metab. 3, 403.
Product Information
CAS number844499-71-4
FormOff-white solid
Hill FormulaC₂₀H₁₂N₂O₃S
Chemical formulaC₂₀H₁₂N₂O₃S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsSoluble in DMSO (mg/ml), EtOH (mg/ml); aliquot and store at -20*C; stable for 6 months.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
171258-5MG 04053252040863

Documentation

AMPK Signaling Activator XV - CAS 844499-71-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

AMPK Signaling Activator XV - CAS 844499-71-4 - Calbiochem Certificates of Analysis

TitleLot Number
171258

References

Reference overview
Sanders, M.J., et al. 2007. J. Biol. Chem. 282, 32539.
Cool, B., et al. 2006. Cell Metab. 3, 403.