171263 AMPK Signaling Activator IX, F17 - CAS 280112-24-5 - Calbiochem

171263
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Key Specifications Table

Empirical FormulaCAS #
C₁₈H₁₉N₃O₃S 280112-24-5

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171263-5MG
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      Glass bottle 5 mg
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      Description
      OverviewA cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~ 0.1 µM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-α1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25 µM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C (Cat. No. 171260).
      Catalogue Number171263
      Brand Family Calbiochem®
      Synonyms4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
      Application Data
      References
      ReferencesLemieux, G.A., et al. 2011. Nat. Chem. Biol. 7, 206.
      Product Information
      CAS number280112-24-5
      FormOff-white solid
      Hill FormulaC₁₈H₁₉N₃O₃S
      Chemical formulaC₁₈H₁₉N₃O₃S
      Quality LevelMQ100
      Applications
      ApplicationThe AMPK Signaling Agonist, F17, also referenced under CAS 280112-24-5, controls the biological activity of AMPK. This AMPK activator and small molecule/inhibitor is primarily used for Biochemicals applications.
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      AMPK Signaling Activator IX, F17 - CAS 280112-24-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      AMPK Signaling Activator IX, F17 - CAS 280112-24-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      171263

      References

      Reference overview
      Lemieux, G.A., et al. 2011. Nat. Chem. Biol. 7, 206.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-April-2012 JSW
      Synonyms4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
      Application Data
      DescriptionA cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~ 0.1 µM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-α1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25 µM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C (Cat. No. 171260).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number280112-24-5
      Chemical formulaC₁₈H₁₉N₃O₃S
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml; clear, colorless solution). Warming to 55-60°C is required for complete solubilization.
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLemieux, G.A., et al. 2011. Nat. Chem. Biol. 7, 206.