504745 AMN082 Dihydrochloride - CAS 97075-46-2 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N,N'-Dibenzhydrylethane-1,2-diamine dihydrochloride

Primary Target: mGlu₇ receptors
504745
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₈H₂₈N₂ • 2HCl 97075-46-2

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.04745.0001
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          		 Glass bottle 10 mg
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          Description
          OverviewA potent, selective and systemically active positive allosteric modulator for mGlu7 receptor (EC50 = 64-290 nM). One of the most frequently used agent for assessing the functional roles of mGlu7 receptors in a variety of brain functions (i.e. sleep pattern, learning and memory, and locomotion) and disorders (i.e. depression, anxiety, and Parkinsons disease). Induces internalization of mGlu7 receptors. Also acts on NMDA, AMPA, 5-HT receptors and norepinephrine transporter.
          Catalogue Number504745
          Brand Family Calbiochem®
          SynonymsN,N'-Dibenzhydrylethane-1,2-diamine dihydrochloride
          References
          ReferencesCavas, M., et al. 2013. Pharmacol. Biochem. Behav. 103, 756.
          Sukoff, R., et al. 2011. J. Pharmacol. Exp. Ther. 338, 345.
          Flor, X., et al. 2005. Neuropharmacology 49, 244.
          Mitsukawa, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 12.
          Greco, B., et al. 2010. J. Pharmacol. Exp. Ther. 332, 1064.
          Pelkey, K., et al. 2007. Neuropharmacology. 52, 108.
          Product Information
          CAS number97075-46-2
          FormWhite solid
          Hill FormulaC₂₈H₂₈N₂ • 2HCl
          Chemical formulaC₂₈H₂₈N₂ • 2HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetmGlu₇ receptors
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          AMN082 Dihydrochloride - CAS 97075-46-2 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Cavas, M., et al. 2013. Pharmacol. Biochem. Behav. 103, 756.
          Sukoff, R., et al. 2011. J. Pharmacol. Exp. Ther. 338, 345.
          Flor, X., et al. 2005. Neuropharmacology 49, 244.
          Mitsukawa, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 12.
          Greco, B., et al. 2010. J. Pharmacol. Exp. Ther. 332, 1064.
          Pelkey, K., et al. 2007. Neuropharmacology. 52, 108.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-July-2013 JSW
          SynonymsN,N'-Dibenzhydrylethane-1,2-diamine dihydrochloride
          DescriptionA potent, selective and systemically active positive allosteric modulator for mGlu7 receptor (EC50 = 64-290 nM). One of the most frequently used agent for assessing the functional roles of mGlu7 receptors in a variety of brain functions (i.e. sleep pattern, learning and memory, and locomotion) and disorders (i.e. depression, anxiety, and Parkinsons disease). Induces internalization of mGlu7 receptors. Also acts on NMDA, AMPA, 5-HT receptors and norepinephrine transporter.
          FormWhite solid
          CAS number97075-46-2
          Chemical formulaC₂₈H₂₈N₂ • 2HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mM)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesCavas, M., et al. 2013. Pharmacol. Biochem. Behav. 103, 756.
          Sukoff, R., et al. 2011. J. Pharmacol. Exp. Ther. 338, 345.
          Flor, X., et al. 2005. Neuropharmacology 49, 244.
          Mitsukawa, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 12.
          Greco, B., et al. 2010. J. Pharmacol. Exp. Ther. 332, 1064.
          Pelkey, K., et al. 2007. Neuropharmacology. 52, 108.