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531170 ALDH3A1 Inhibitor, CB29 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₅H₁₅N₃O₅S

Products

Catalog NumberPackaging Qty/Pack
5.31170.0001 Glass bottle 25 mg
Description
OverviewA cell permeable diarylamine derivative that acts as a selective, reversible, substrate-binding site directed inhibitor of aldehyde dehydrogenase ALDH3A1 (Ki = 4.7 µM, IC50 = 16 µM). Does not inhibit the activity of ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, and ALDH2 even at higher concentrations (250 µM). Shown to significantly reduce the activity of ALDH3A1 in A549 and SF767 cell lysates, but does not affect CCD-13Lu cells that lack ALDH3A1 activity. Although it does not affect tumor cell proliferation, it significantly improves the sensitivity of cancer cells to mafosfamide.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number531170
Brand Family Calbiochem®
SynonymsAldehyde dehydrogenase ALDH3A1 inhibitor, CB29
References
ReferencesParajuli, B. et al. 2014. Chembiochem. 15, 701.
Product Information
FormYellow powder
Hill FormulaC₁₅H₁₅N₃O₅S
Chemical formulaC₁₅H₁₅N₃O₅S
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetALDH3A1
Primary Target K<sub>i</sub>4.7 µ
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.31170.0001 04055977242669

Documentation

ALDH3A1 Inhibitor, CB29 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Parajuli, B. et al. 2014. Chembiochem. 15, 701.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-August-2014 JSW
SynonymsAldehyde dehydrogenase ALDH3A1 inhibitor, CB29
DescriptionA cell permeable diarylamine derivative that acts as a selective, reversible, substrate-binding site directed inhibitor of aldehyde dehydrogenase ALDH3A1 (Ki = 4.7 µM, IC50 = 16 µM). Does not inhibit the activity of ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, and ALDH2 even at higher concentrations (250 µM). Shown to significantly reduce the activity of ALDH3A1 in A549 and SF767 cell lysates, but does not affect CCD-13Lu cells that lack ALDH3A1 activity. Although it does not affect tumor cell proliferation, it significantly improves the sensitivity of cancer cells to mafosfamide.
FormYellow powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₅H₁₅N₃O₅S
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesParajuli, B. et al. 2014. Chembiochem. 15, 701.