531170 ALDH3A1 Inhibitor, CB29 - Calbiochem

531170
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₅H₁₅N₃O₅S

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      Glass bottle 25 mg
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      Description
      OverviewA cell permeable diarylamine derivative that acts as a selective, reversible, substrate-binding site directed inhibitor of aldehyde dehydrogenase ALDH3A1 (Ki = 4.7 µM, IC50 = 16 µM). Does not inhibit the activity of ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, and ALDH2 even at higher concentrations (250 µM). Shown to significantly reduce the activity of ALDH3A1 in A549 and SF767 cell lysates, but does not affect CCD-13Lu cells that lack ALDH3A1 activity. Although it does not affect tumor cell proliferation, it significantly improves the sensitivity of cancer cells to mafosfamide.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531170
      Brand Family Calbiochem®
      SynonymsAldehyde dehydrogenase ALDH3A1 inhibitor, CB29
      References
      ReferencesParajuli, B. et al. 2014. Chembiochem. 15, 701.
      Product Information
      FormYellow powder
      Hill FormulaC₁₅H₁₅N₃O₅S
      Chemical formulaC₁₅H₁₅N₃O₅S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetALDH3A1
      Primary Target K<sub>i</sub>4.7 µ
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      ALDH3A1 Inhibitor, CB29 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Parajuli, B. et al. 2014. Chembiochem. 15, 701.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-August-2014 JSW
      SynonymsAldehyde dehydrogenase ALDH3A1 inhibitor, CB29
      DescriptionA cell permeable diarylamine derivative that acts as a selective, reversible, substrate-binding site directed inhibitor of aldehyde dehydrogenase ALDH3A1 (Ki = 4.7 µM, IC50 = 16 µM). Does not inhibit the activity of ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, and ALDH2 even at higher concentrations (250 µM). Shown to significantly reduce the activity of ALDH3A1 in A549 and SF767 cell lysates, but does not affect CCD-13Lu cells that lack ALDH3A1 activity. Although it does not affect tumor cell proliferation, it significantly improves the sensitivity of cancer cells to mafosfamide.
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₅H₁₅N₃O₅S
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesParajuli, B. et al. 2014. Chembiochem. 15, 701.