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505478 A317491 - CAS 475205-49-3 - Calbiochem

505478
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Empirical FormulaCAS #
C₃₃H₂₇NO₈•xH2O•xNa 475205-49-3

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      Glass bottle 5 mg
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      Description
      OverviewA potent, selective, and competitive non-nucleotide antagonist of P2X3 and P2X2/3 receptors that blocks receptor-mediated Ca2+ flux (Ki = 22 and 92 nM for rat P2X3 and P2X2/3 receptor and 22 and 9 nM for human P2X3 and P2X2/3 receptor, respectively). Its R-enantiomer has significantly reduced activity at these receptors. Exhibits high selectivity over other purinergic receptors. Shown to reduce thermal and mechanical hyperalgesia in rat models (ED50 = 10-15 µM/kg, s.c). Its anti-nociceptive effects have a rapid on-set and persist for up to 5 hours after sub-cutaneous administration. Also shown to block dorsal root ganglion currents in a dose-dependent manner (IC50 = 15 nM).
      Catalogue Number505478
      Brand Family Calbiochem®
      Synonyms(S)-5-((3-phenoxybenzyl)(1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)benzene-1,2,4-tricarboxylic acid, P2X3 Purinergic Receptors Antagonist, A317491, P2X2/3 Purinergic Receptors Antagonist, A317491, A 317491
      References
      ReferencesJarvis, MF. et al. 2002. Proc. Natl. Acad. Sci. USA 99, 17179.
      Product Information
      CAS number475205-49-3
      FormWhite powder
      Hill FormulaC₃₃H₂₇NO₈•xH2O•xNa
      Chemical formulaC₃₃H₂₇NO₈•xH2O•xNa
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetP2X3
      Primary Target K<sub>i</sub>22nM
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      A317491 - CAS 475205-49-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Jarvis, MF. et al. 2002. Proc. Natl. Acad. Sci. USA 99, 17179.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2013 JSW
      Synonyms(S)-5-((3-phenoxybenzyl)(1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)benzene-1,2,4-tricarboxylic acid, P2X3 Purinergic Receptors Antagonist, A317491, P2X2/3 Purinergic Receptors Antagonist, A317491, A 317491
      DescriptionA potent, selective, and competitive non-nucleotide antagonist of P2X3 and P2X2/3 receptors that blocks receptor-mediated Ca2+ flux (Ki = 22 and 92 nM for rat P2X3 and P2X2/3 receptor and 22 and 9 nM for human P2X3 and P2X2/3 receptor, respectively). Its R-enantiomer has significantly reduced activity at these receptors. Exhibits high selectivity over other purinergic receptors. Shown to reduce thermal and mechanical hyperalgesia in rat models (ED50 = 10-15 µM/kg, s.c). Its anti-nociceptive effects have a rapid on-set and persist for up to 5 hours after sub-cutaneous administration. Also shown to block dorsal root ganglion currents in a dose-dependent manner (IC50 = 15 nM).
      FormWhite powder
      CAS number475205-49-3
      Chemical formulaC₃₃H₂₇NO₈•xH2O•xNa
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityH₂O (50 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesJarvis, MF. et al. 2002. Proc. Natl. Acad. Sci. USA 99, 17179.