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407294 αA-Interferon, Human, Recombinant, E. coli

407294
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407294-5MU
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      Description
      OverviewRecombinant, human αA-interferon expressed in E. coli. Antiviral, anti-neoplastic agent. αA-Interferon exhibits therapeutic potential with chronic viral hepatitis, polycythemia vera, and various malignancies. It enhances natural killer cell activity, suppresses bone marrow function, and induces apoptotic cell death in non-melanoma skin cancer. NOTE: 1MU = 1,000,000 units.
      Note: 1 MU = 1,000,000 units.
      Catalogue Number407294
      Brand Family Calbiochem®
      SynonymsrhIFN-αA
      References
      ReferencesFujishima, H., et al. 1998. Int. J. Cancer 76, 423.
      Haria, M., and Benfield, P. 1995. Drugs 50, 873.
      Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.
      Product Information
      Activity≥5 x 10⁶ units/ml
      Unit of DefinitionOne unit of interferon per ml of medium will cause a 50% inhibition of VSV-induced cytopathic effect on bovine MDBK cells. Units are determined with respect to the NIH international reference standard for human αA-IFN. Dilute in aqueous buffer containing at least 0.1% BSA or HSA.
      FormLiquid
      FormulationIn PBS containing 0.1% BSA.
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by SDS-PAGE
      Specific Activity≥2.8 x 10⁸ units/mg protein
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      αA-Interferon, Human, Recombinant, E. coli SDS

      Title

      Safety Data Sheet (SDS) 

      αA-Interferon, Human, Recombinant, E. coli Certificates of Analysis

      TitleLot Number
      407294

      References

      Reference overview
      Fujishima, H., et al. 1998. Int. J. Cancer 76, 423.
      Haria, M., and Benfield, P. 1995. Drugs 50, 873.
      Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.

      Citations

      Title
    • Sambit K. Nanda and Michael D. Baron. (2006) Rinderpest virus blocks type I and type II interferon action: role of structural and nonstructural proteins. Journal of Virology 80, 7555-7568.
    • Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-May-2008 RFH
      SynonymsrhIFN-αA
      DescriptionRecombinant, human αA-interferon expressed in E. coli. Antiviral, anti-neoplastic agent. αA-Interferon exhibits therapeutic potential in chronic viral hepatitis, polycythemia vera, and various malignancies. It enhances natural killer cell activity, suppresses bone marrow function, and induces apoptotic cell death in non-melanoma skin cancer.
      FormLiquid
      FormulationIn PBS containing 0.1% BSA.
      Purity≥95% by SDS-PAGE
      Specific activity≥2.8 x 10⁸ units/mg protein
      Activity≥5 x 10⁶ units/ml
      Unit definitionOne unit of interferon per ml of medium will cause a 50% inhibition of VSV-induced cytopathic effect on bovine MDBK cells. Units are determined with respect to the NIH international reference standard for human αA-IFN. Dilute in aqueous buffer containing at least 0.1% BSA or HSA.
      SolubilityDilute only in buffers containing protein such as 0.1% BSA.
      Storage ≤ -70°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      Merck USA index14, 4990
      ReferencesFujishima, H., et al. 1998. Int. J. Cancer 76, 423.
      Haria, M., and Benfield, P. 1995. Drugs 50, 873.
      Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.
      Citation
    • Sambit K. Nanda and Michael D. Baron. (2006) Rinderpest virus blocks type I and type II interferon action: role of structural and nonstructural proteins. Journal of Virology 80, 7555-7568.
    • Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.
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      Categories

      Life Science Research > Proteins and Enzymes > Other Proteins