531619 2-Aminopurine - CAS 452-06-2 - Calbiochem

531619
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₅H₅N₅ 452-06-2

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      Glass bottle 250 mg
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      Description
      OverviewA cell permeable adenine analog that is widely used as a versatile fluorescent probe to investigate RNA and DNA secondary and tertiary structures and their conformation dynamics in response to local environment when interacting with other biomolecules with great sensitivity. Forms stable base pairs with neucleobase uracil found in RNA and thymine in DNA, and moderately stable base pairs with cytosine. Exhibits intensive fluorescence emission (lAbsmax = 303 nM, lflmax = 370 nM, and fluorescence quantum yield in solution QFI = 0.68) and longer excitation wavelength compared with other neucleobases enabling its selective excitation with low background signals.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531619
      Brand Family Calbiochem®
      Synonyms2-AP, 2AP
      References
      ReferencesMa, L., et al. 2014. Biochem. Biophys. Res. Comm. 449, 120.
      Widom, J. R., et al. 2013. New. J. Phys. 15, 025028.
      Souliere, M. F., et al. 2011. J. Am. Chem. Soc. 133, 16161,
      Jean, J. M., et al. 2001. PNAS 98,37.
      Product Information
      CAS number452-06-2
      FormYellow powder
      Hill FormulaC₅H₅N₅
      Chemical formulaC₅H₅N₅
      ReversibleY
      Quality LevelMQ200
      Applications
      Biological Information
      Primary TargetDNA and RNA
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Emission max.
      Excitation max.
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      2-Aminopurine - CAS 452-06-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Ma, L., et al. 2014. Biochem. Biophys. Res. Comm. 449, 120.
      Widom, J. R., et al. 2013. New. J. Phys. 15, 025028.
      Souliere, M. F., et al. 2011. J. Am. Chem. Soc. 133, 16161,
      Jean, J. M., et al. 2001. PNAS 98,37.

      Brochure

      Title
      NPI Flyer- Epigenetics and Nuclear Function Feature (EMD)
      New Products - Antibodies, Small Molecule, Inhibitors

      Technical Info

      Title
      White Paper: Further considerations of antibody validation and usage. (EMD)
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-December-2014 JSW
      Synonyms2-AP, 2AP
      DescriptionA cell permeable adenine analog that is widely used as a versatile fluorescent probe to investigate RNA and DNA secondary and tertiary structures and their conformation dynamics in response to local environment when interacting with other biomolecules with great sensitivity. Forms stable base pairs with neucleobase uracil found in RNA and thymine in DNA, and moderately stable base pairs with cytosine. Exhibits intensive fluorescence emission (lAbsmax = 303 nM, lflmax = 370 nM, and fluorescence quantum yield in solution QFI = 0.68) and longer excitation wavelength compared with other neucleobases enabling its selective excitation with low background signals.
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number452-06-2
      Chemical formulaC₅H₅N₅
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesMa, L., et al. 2014. Biochem. Biophys. Res. Comm. 449, 120.
      Widom, J. R., et al. 2013. New. J. Phys. 15, 025028.
      Souliere, M. F., et al. 2011. J. Am. Chem. Soc. 133, 16161,
      Jean, J. M., et al. 2001. PNAS 98,37.