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500587 γ-Secretase Inhibitor XXV, FT-9 - Calbiochem

Overview

Replacement Information

Products

Catalog NumberPackaging Qty/Pack
500587-10MG Glass bottle 10 mg
Description
OverviewFT-9, a cell-permeable NSAID-like compound, is a partially selective γ-Secretase Inhibitor in both microsomes and whole cells. Displays dose-dependent inhibition of the γ-secretase cleavage of β-Amyloid Precursor Protein (APP) and APLP2 with IC50 values against APP ICD (intracellular domain) and APLP2 ICD of ˜260 µM, but there is a less potent effect on γ-secretase processing of APLP1. The concentration of FT-9 required to cause a 2-fold increase in APP CTFs, 3.4 +/- 0.4 µM, is significantly lower than that for APLP1 (25.7 +/- 8.9 µM) (P = 0.001). For comparison, the concentration of another γ-Secretase inhibitor compound E (EMD Chemicals, Inc. Cat. No. 565790) needed for a 2-fold increase in the magnitude of the CTF band signal is not significantly different, being 0.27 nM for APP versus 0.24 nM for APLP1. This is the first example that a GSI can preferentially target APP processing while sparing other γ-substrates.
Catalogue Number500587
Brand Family Calbiochem®
Synonyms2-[3-(3,5-dichlorophenoxy)phenyl]propanoic acid
References
ReferencesSala Frigerio, C., et al. 2009. Biochemistry 48, 10894.
Kukar, TL., et al. 2008. Nature 453, 925.
Product Information
FormOff-white powder
Hill FormulaC₁₅H₁₂Cl₂O₃
Chemical formulaC₁₅H₁₂Cl₂O₃
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
500587-10MG4055977199369

Documentation

γ-Secretase Inhibitor XXV, FT-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Sala Frigerio, C., et al. 2009. Biochemistry 48, 10894.
Kukar, TL., et al. 2008. Nature 453, 925.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-June-2013 JSW
Synonyms2-[3-(3,5-dichlorophenoxy)phenyl]propanoic acid
DescriptionFT-9, a cell-permeable NSAID-like compound, is a partially selective γ-Secretase Inhibitor in both microsomes and whole cells. Displays dose-dependent inhibition of the γ-secretase cleavage of β-Amyloid Precursor Protein (APP) and APLP2 with IC50 values against APP ICD (intracellular domain) and APLP2 ICD of ˜260 µM, but there is a less potent effect on γ-secretase processing of APLP1. The concentration of FT-9 required to cause a 2-fold increase in APP CTFs, 3.4 +/- 0.4 µM, is significantly lower than that for APLP1 (25.7 +/- 8.9 µM) (P = 0.001). For comparison, the concentration of another γ-Secretase inhibitor compound E (EMD Chemicals, Inc. Cat. No. 565790) needed for a 2-fold increase in the magnitude of the CTF band signal is not significantly different, being 0.27 nM for APP versus 0.24 nM for APLP1. This is the first example that a GSI can preferentially target APP processing while sparing other γ-substrates.
FormOff-white powder
Chemical formulaC₁₅H₁₂Cl₂O₃
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSala Frigerio, C., et al. 2009. Biochemistry 48, 10894.
Kukar, TL., et al. 2008. Nature 453, 925.