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Description
Overview
A potent, selective dopamine D2 receptor agonist with a Ki value of 4.8 nM. Some D3(Ki = 24 nM) and D4 (Ki = 30 nM) receptor agonistic action has also been reported. In rat striatum studies in vitro, application of quinpriole inhibited single pulse dopamine overflow in a concentration-dependent manner (IC50 = 32.5 nM).
OʹNeill, C. et al. 2009. J. Neurochem.108, 545. Malmberg, A. and Mohell, N. 1995. J. Pharmacol. Exp. Ther.274, 790. Seeman, P. and Schaus, J. M. 1991. Eur. J. Pharmacol.203, 105.
OʹNeill, C. et al. 2009. J. Neurochem.108, 545. Malmberg, A. and Mohell, N. 1995. J. Pharmacol. Exp. Ther.274, 790. Seeman, P. and Schaus, J. M. 1991. Eur. J. Pharmacol.203, 105.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A potent, selective dopamine D2 receptor agonist with a Ki value of 4.8 nM. Some D3(Ki = 24 nM) and D4 (Ki = 30 nM) receptor agonistic action has also been reported. In rat striatum studies in vitro, application of quinpriole inhibited single pulse dopamine overflow in a concentration-dependent manner (IC50 = 32.5 nM).
Form
White powder
CAS number
85798-08-9
Chemical formula
C₁₃H₂₁N₃•HCl
Structure formula
Purity
≥98% by HPLC
Solubility
H₂O (7.3 mg/ml)
Storage
Protect from light
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
OʹNeill, C. et al. 2009. J. Neurochem.108, 545. Malmberg, A. and Mohell, N. 1995. J. Pharmacol. Exp. Ther.274, 790. Seeman, P. and Schaus, J. M. 1991. Eur. J. Pharmacol.203, 105.