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407293 α-Interferon, Mouse, Recombinant, E. coli

407293
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407293-100KU
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      Description
      OverviewRecombinant, mouse α-interferon expressed in E. coli. Antiviral and anti-neoplastic agent. Suppresses bone marrow function and induces apoptotic cell death in non-melanoma skin cancer. IFN-α signaling is mediated by JAK1 and TYK2 tyrosine kinases. Note: 1 KU = 1000 units.
      Catalogue Number407293
      Brand Family Calbiochem®
      References
      ReferencesKrishnan, K., et al. 1997. Eur. J. Biochem. 247, 298.
      Rodriquez-Villanueva, S., and McDonnel, T.J. 1995. Int. J. Cancer 61, 110.
      Dianzani, F. 1993. Gut 34, 574.
      Brouty-Boyce, D., and Zetter, B.R. 1990. Science 208, 516.
      Sidky, Y.A., and Borden, E.C. 1987. Cancer Res. 47, 5155.
      Daugherty, B.L., and Pestka, S. 1986. Methods Enzymol. 119, 34.
      Pestka, S. 1986. Methods Enzymol. 119, 14.
      Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.
      Johnson, M.D., et al. 1981. Methods Enzymol. 78, 394.
      Rubinstein, S., et al. 1981. J. Virol. 37, 755.
      Product Information
      Activity≥3.5 x 10⁴ units/ml
      Unit of DefinitionOne unit of interferon per ml of medium will cause a 50% inhibition of EMCV-induced cytopathic effect on mouse L929 cells. Units are determined with respect to the NIH international reference standard for mouse IFN-α.
      FormLiquid
      FormulationIn PBS containing 0.1% BSA.
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by SDS-PAGE
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      α-Interferon, Mouse, Recombinant, E. coli SDS

      Title

      Safety Data Sheet (SDS) 

      α-Interferon, Mouse, Recombinant, E. coli Certificates of Analysis

      TitleLot Number
      407293

      References

      Reference overview
      Krishnan, K., et al. 1997. Eur. J. Biochem. 247, 298.
      Rodriquez-Villanueva, S., and McDonnel, T.J. 1995. Int. J. Cancer 61, 110.
      Dianzani, F. 1993. Gut 34, 574.
      Brouty-Boyce, D., and Zetter, B.R. 1990. Science 208, 516.
      Sidky, Y.A., and Borden, E.C. 1987. Cancer Res. 47, 5155.
      Daugherty, B.L., and Pestka, S. 1986. Methods Enzymol. 119, 34.
      Pestka, S. 1986. Methods Enzymol. 119, 14.
      Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.
      Johnson, M.D., et al. 1981. Methods Enzymol. 78, 394.
      Rubinstein, S., et al. 1981. J. Virol. 37, 755.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-December-2008 JSW
      DescriptionRecombinant, mouse α-interferon expressed in E. coli. Antiviral, antineoplastic agent. Expressed during the triggering stage of macrophage cytocidal activation. Suppresses bone marrow function and cell proliferation. Modulates the immune response. Also known to induce apoptotic cell death in non-melanoma skin cancer.
      FormLiquid
      FormulationIn PBS containing 0.1% BSA.
      Purity≥95% by SDS-PAGE
      Activity≥3.5 x 10⁴ units/ml
      Unit definitionOne unit of interferon per ml of medium will cause a 50% inhibition of EMCV-induced cytopathic effect on mouse L929 cells. Units are determined with respect to the NIH international reference standard for mouse IFN-α.
      Storage ≤ -70°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      Merck USA index14, 4990
      ReferencesKrishnan, K., et al. 1997. Eur. J. Biochem. 247, 298.
      Rodriquez-Villanueva, S., and McDonnel, T.J. 1995. Int. J. Cancer 61, 110.
      Dianzani, F. 1993. Gut 34, 574.
      Brouty-Boyce, D., and Zetter, B.R. 1990. Science 208, 516.
      Sidky, Y.A., and Borden, E.C. 1987. Cancer Res. 47, 5155.
      Daugherty, B.L., and Pestka, S. 1986. Methods Enzymol. 119, 34.
      Pestka, S. 1986. Methods Enzymol. 119, 14.
      Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.
      Johnson, M.D., et al. 1981. Methods Enzymol. 78, 394.
      Rubinstein, S., et al. 1981. J. Virol. 37, 755.

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      Categories

      Life Science Research > Proteins and Enzymes > Other Proteins