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219334 β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem

219334
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Key Specifications Table

Empirical FormulaCAS #
C₃₂H₃₆Cl₂Cu₂N₂O₂ 691005-38-6

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219334-10MG
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      Description
      OverviewA cell-permeable dimeric copper complex that competitively binds β-catenin and disrupts β-catenin/Tcf4 interaction reversibly (IC50 = 5.0 µM), and acts as a Wnt signaling inhibitor. Shown to induce preferential growth arrest in β-catenin overexpressing HCT116 colon cancer and HEK293 cells (≤ 10 µM), and downregulate mRNA expressions of c-Myc and cyclin D1. Reported to inhibit PP2C and proteasomal activities at higher concentrations (~50 µM).
      Catalogue Number219334
      Brand Family Calbiochem®
      SynonymsCopper, di-µ-chlorobis[1-[(1-piperidinyl-κN)methyl]-2-naphthalenolato-κO]di-(9Cl), Wnt Pathway Inhibitor XV
      References
      ReferencesTian, W., et al. 2012. Biochemistry 51, 724.
      Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658.
      Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.
      Product Information
      CAS number691005-38-6
      FormDark brown solid
      Hill FormulaC₃₂H₃₆Cl₂Cu₂N₂O₂
      Chemical formulaC₃₂H₃₆Cl₂Cu₂N₂O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by Elemental Analysis
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot, freeze (≥-70°C). Stock solutions are stable for up to 12 months at ≥-70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      219334

      References

      Reference overview
      Tian, W., et al. 2012. Biochemistry 51, 724.
      Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658.
      Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-February-2017 JSW
      SynonymsCopper, di-µ-chlorobis[1-[(1-piperidinyl-κN)methyl]-2-naphthalenolato-κO]di-(9Cl), Wnt Pathway Inhibitor XV
      DescriptionA cell-permeable dimeric copper complex that competitively binds β-catenin and disrupts β-catenin/Tcf4 interaction reversibly (IC50 = 5.0 µM), and acts as a Wnt signaling inhibitor. Shown to induce preferential growth arrest in β-catenin overexpressing HCT116 colon cancer and HEK293 cells (≤ 10 µM), and downregulate mRNA expressions of c-Myc and cyclin D1. Reported to inhibit PP2C and proteasomal activities at higher concentrations (~50 µM).
      FormDark brown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number691005-38-6
      Chemical formulaC₃₂H₃₆Cl₂Cu₂N₂O₂
      Structure formulaStructure formula
      Purity≥95% by Elemental Analysis
      SolubilityDMSO (0.5 mg/ml). Poorly soluble in water.
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot, freeze (≥-70°C). Stock solutions are stable for up to 12 months at ≥-70°C.
      Toxicity Standard Handling
      ReferencesTian, W., et al. 2012. Biochemistry 51, 724.
      Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658.
      Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.