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Endocrine Disruptor Chemical Testing
Our Custom Assay Service helped bring MILLIPLEX® to EDC testing.Read Article
Application Notes |
Read our app note and DD&D article about drug-induced liver injury in rat samples using our MILLIPLEX® MAP rat assays.
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Read about a kidney tox study with our 14 MILLIPLEX® MAP rat kidney toxicity biomarkers. 
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Read App Note |
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Toxicology Wall Poster
Toxicology in drug discovery an development: Biomarkers and model organisms.Download Poster
Measure Toxicity Biomarkers with MILLIPLEX®
MAP Multiplexed Assay Kits.
Toxicity affects all facets of biological research and drug development. A guiding tenet in toxicity studies is to eliminate toxic compounds as early as possible in the drug development process. Organ-specific toxicity testing is of chief importance because drug-induced toxicities in various organs are the leading cause of drug failure.
The ideal toxicity biomarkers are not only organ- or tissue-specific, but are also sensitive enough to identify organ or tissue damage before it becomes too extensive. The Predictive Safety Testing Consortium (PSTC), with whom we partnered, identified and qualified a number of protein biomarkers that may better predict organ-specific toxicity, and regulatory agencies have recommended assay characteristics for establishing toxicity. Furthermore, toxicity biomarkers should ideally be applicable to preclinical models in which early safety is frequently assessed.
In addition to regulatory requirements in drug development, endocrine disruptor chemical (EDC) testing has been mandated by environmental regulatory agencies worldwide. New chemical entities, and even older pesticides, environmental chemicals and food additives, are required to be tested for their capacity to disrupt human and animal developmental and reproductive health.
Bring Your Toxicity Biomarkers to Life with MILLIPLEX® MAP Multiplex Toxicity Assays
Bead-based multiplex assays enable precise, multiparametric analysis of toxicity and underlying processes. Our MILLIPLEX®
MAP multiplex toxicity biomarker assay kits enable you to simultaneously quantify dozens of toxicity analytes across several species (including rat, mouse, porcine, canine, and feline models).
Based on
Luminex xMAP® technology, our analytically validated assay kits provide:
- Standards validated to match reference lots
- Serum matrix for generating standard curves that accurately simulate conditions of native analyte conditions in serum or plasma
- In-assay controls
- Detection antibody cocktails to ensure consistent performance regardless of plex size
- A way to save precious sample. Determine how much sample is needed using the table here.
Some examples of the toxicity multiplex assay analytes in our portfolio are listed below.
Kidney Toxicity*:
Detecting qualified kidney toxicity biomarkers, in contrast to traditional BUN and serum creatinine tests, can enable early detection and localization of kidney damage, which are crucial for accurate assessment of toxicity.
*selected analytes shown
Liver Injury*:
These biomarkers are hepatocellular and hepatobiliary enzymes that are released into circulation upon occurrence of liver injury:
*selected analytes shown
Vascular Injury*:
In addition to heart rate and mean arterial blood pressure, measuring key proteins in smooth muscle, endothelial cells, and immune-mediated cells may yield promising biomarkers:
*selected analytes shown
Endocrine Disruptor Chemicals (EDC)*:
Reproductive, adrenal, thyroid and pituitary hormone levels and their functions in humans and animals can be altered with exposure to EDCs.
In vitro cell assays and
in vivo models for various species may be used to assess the effects of chemical exposure.
*selected analytes shown
Expand the Power of Your Toxicity Research
In early stages, toxicity testing means evaluating the effect of compounds on cell signaling pathways.
Explore our assay kits for:
Cellular metabolism and signaling pathways (Intracellular Assays)
Download the Analyte Quarterly brochure for a complete, updated list of assays.
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