Millipore Sigma Vibrant Logo
Attention: We have moved. EMD Millipore products are no longer available for purchase on More

Read All About It!

Stay up to date in analytical chromatography with MilliporeSigma. Our brochures and guides offer valuable information about techniques and products that can support and optimize your investigations. Simply download your preferred literature from the list below, and remember to check back regularly for new publications.

HPLC Troubleshooting Guide

Untangle Your Liquid Chromatography Problems
HPLC Troubleshooting Guide
HPLC Troubleshooting Guide Our new, easy to use HPLC Troubleshooting Guide is organized into chapters covering the most common problems encountered in liquid chromatography.
  • Retention
  • Equilibration
  • Peaks
  • Recovery
  • Leaks
  • Selectivity
  • Baseline
  • Pressure

Order Your FREE Copy Here

Overview Catalog

The world of chromatography in your hands
  • In depth information covering MilliporeSigma's chromatography products
  • Information about water purification systems and sample preparation
  • Method development support and applications, particulary for meeting pharmacopoeia requirements
  • Column selection guide and troubleshooting advice

More Information 
Order a Printed Copy

TLC/HPTLC Brochure

Fast and Precise
Thin Layer Chromatography by MilliporeSigma

Technique: Thin Layer Chromatography
Product(s): TLC and HPTLC product range

  • Complete portfolio of TLC, HPTLC, and PLC plates
  • Fast, inexpensive method for qualitative and quantitative analysis
  • Simultaneous analysis of several samples under identical conditions

View & Download

Analytical HPLC and UHPLC Brochures


Do you need trouble-free speed?
The new Chromolith® HR

Technique: Analytical HPLC
Product(s): Chromolith® HighResolution HPLC Columns

  • Fast separations with easy method transfer
  • Column performance corresponds to 3 µm particle packed column, and is at least 50% higher than standard Chromolith® columns
  • Back pressure around 2 times lower than particle packed columns
  • 30% longer column lifetime compared to particle packed columns

View & Download


Purospher® STAR HPLC and UHPLC column
Outstanding performance  
Merck:/Freestyle/LE-Lab-Essentials/Chromatography/Brochures/LE-Purospher Broschure MM-200x266-02122014.jpg

Technique: Analytical HPLC
Product(s): Purospher® STAR and UHPLC columns®

  • Best in class RP-18e column for excellent peak symmetry, performance and pH stability
  • Less hydrophobic compounds, faster retention of very hydrophobic compounds
  • Enhanced selectivity for separation of aromatic compounds due to π-π interactions
  • Separation of carbohydrates and polar compounds with normal-phase or HILIC chromatography
  • Separation of polar compounds with normal-phase or HILIC (Si) chromatography
  • Ultra fast for UHPLC and excellent for LC-MS

View & Download


For all who expect more

Technique: Analytical HPLC
Product(s): SeQuant® ZIC® -HILIC HPLC columns

  • High-performance, advanced hydrophilic interaction liquid chromatography
  • SeQuant® ZIC® -HILIC for the separation of all polar and hydrophilic compounds
  • SeQuant® ZIC®-pHILIC for challenging separations of polar and hydrophilic compounds

View & Download

It's hot!
SeQuant® ZIC® -cHILIC

Technique: Analytical HPLC
Product(s): SeQuant® ZIC® -cHILIC HPLC columns

  • High-performance HILIC columns with complementary selectivity for HPLC separation of polar hydrophilic compounds
  • Maximum LC-MS compatibility with minimized column bleed, excellent reproducibility and robustness

View & Download

HPLC Application Collections

HPLC Application Collections

Application Notes and Methods

Learn More